Kruk Irena, Bozdağ-Dündar Oya, Ertan Rahmiye, Aboul-Enein Hassan Y, Michalska Teresa
Institute of Physics, Szczecin University of Technology, Al. Piastów 48/49, 70-311 Szczecin, Poland.
Luminescence. 2009 Mar-Apr;24(2):96-101. doi: 10.1002/bio.1077.
The oxygen free radical scavenging activities of 15 chromonyl-thiazolidine-2,4-dione compounds (CTDs) were examined in chemical systems producing superoxide anion radicals, O2(-) (potassium superoxide-18-crown-6 ether-DMSO), and hydroxyl radicals, HO() (a Fenton reaction: Fe(II)-H2O2-sodium trifluoroacetate, pH 6.15). Chemiluminescence and electron spin resonance (ESR) spectroscopy using 5,5-dimethyl-1-pyrroline-1-oxide (DMPO) as spin trap were applied to evaluate antioxidant behaviour of CTDs towards the oxygen radicals. The results indicated that 11 of the 15 tested compounds showed a significant inhibitory effect on the chemiluminescence generated from the O2(-*)-generating system, ranging from 41 to 86%, and 13 CTDs quenched the ESR signal of the DMPO-OH spin adduct by 33-86%, at a concentration of 1 mmol L(-1). Our findings demonstrate that CTDs could be good free radical scavengers.
在产生超氧阴离子自由基O₂⁻˙（超氧化钾-18-冠-6-醚-二甲基亚砜）和羟基自由基HO˙（芬顿反应：Fe(II)-H₂O₂-三氟乙酸钠，pH 6.15）的化学体系中，检测了15种色酮基-噻唑烷-2,4-二酮化合物（CTD）的氧自由基清除活性。使用5,5-二甲基-1-吡咯啉-1-氧化物（DMPO）作为自旋捕获剂的化学发光和电子自旋共振（ESR）光谱法，用于评估CTD对氧自由基的抗氧化行为。结果表明，15种受试化合物中的11种对O₂⁻˙产生体系产生的化学发光表现出显著抑制作用，抑制率在41%至86%之间；在浓度为1 mmol L⁻¹时，13种CTD使DMPO-OH自旋加合物的ESR信号猝灭33%至86%。我们的研究结果表明，CTD可能是良好的自由基清除剂。
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