Goto Yukiori, Grace Anthony A
Department of Psychiatry, McGill University, Montreal, Quebec, H3A 1A1, Canada.
Trends Neurosci. 2008 Nov;31(11):552-8. doi: 10.1016/j.tins.2008.08.002. Epub 2008 Sep 9.
The nucleus accumbens regulates goal-directed behaviors by integrating information from limbic structures and the prefrontal cortex. Here, we review recent studies in an attempt to provide an integrated view of the control of information processing in the nucleus accumbens in terms of the regulation of goal-directed behaviors and how disruption of these functions might underlie the pathological states in drug addiction and other psychiatric disorders. We propose a model that could account for the results of several studies investigating limbic-system interactions in the nucleus accumbens and their modulation by dopamine and provide testable hypotheses for how these might relate to the pathophysiology of major psychiatric disorders.
伏隔核通过整合来自边缘系统结构和前额叶皮质的信息来调节目标导向行为。在此,我们回顾近期的研究,试图从目标导向行为的调节以及这些功能的破坏如何可能成为药物成瘾和其他精神疾病病理状态的基础等方面,对伏隔核中信息处理的控制提供一个综合观点。我们提出一个模型,该模型可以解释几项研究伏隔核中边缘系统相互作用及其受多巴胺调节的结果,并为这些相互作用如何可能与主要精神疾病的病理生理学相关提供可检验的假设。