在一名患有青少年慢性粒细胞白血病且并发移植物失败的患者接受非亲缘供者异基因骨髓移植后，通过粒细胞巨噬细胞集落刺激因子（GM-CSF）和白细胞介素-3（IL-3）成功刺激自体骨髓恢复。
Successful stimulation of autologous bone marrow recovery by GM-CSF and IL-3 after an unrelated donor BMT for juvenile CML complicated by graft failure.
作者信息
Suttorp M, Schmitz N, Prange E, Ganser A, Löffler H, Schaub J
机构信息
Dept. of Pediatrics, Univ. of Kiel, FRG.
出版信息
Bone Marrow Transplant. 1991;7 Suppl 2:84.
We report the case of a boy with juvenile chronic myeloid leukemia (jCML), who after initial treatment with interferon alpha-2 (IFN) and hydroxyurea underwent bone marrow transplantation (BMT) from a matched unrelated donor complicated by graft failure. Subsequent stimulation of hematopoiesis by GM-CSF and IL-3 promoted autologous recovery. In contrast to the course of disease pre-BMT, the boy is now off any therapy remaining in complete remission more than 500 days after BMT.
我们报告了一名患有青少年慢性髓性白血病（jCML）的男孩的病例，该男孩在先用α-2干扰素（IFN）和羟基脲进行初始治疗后，接受了来自匹配无关供者的骨髓移植（BMT），但并发了移植物失败。随后用粒细胞-巨噬细胞集落刺激因子（GM-CSF）和白细胞介素-3（IL-3）刺激造血促进了自体恢复。与BMT前的病程不同，该男孩现在已停止任何治疗，在BMT后500多天仍处于完全缓解状态。
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