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非亲缘骨髓移植移植失败后,通过粒细胞巨噬细胞集落刺激因子(GM-CSF)和白细胞介素-3(IL-3)促进骨髓功能自体恢复,幼年慢性粒细胞白血病得以缓解。

Remission of juvenile chronic myeloid leukemia following graft failure of an unrelated marrow transplant and autologous recovery of marrow function promoted by GM-CSF and IL-3.

作者信息

Suttorp M, Schmitz N, Prange E, Oster W, Löffler H, Schaub J, Ganser A

机构信息

Department of Pediatrics, University of Kiel, Germany.

出版信息

Leukemia. 1991 Aug;5(8):723-5.

PMID:1886426
Abstract

The unusual course of a boy with juvenile chronic myeloid leukaemia is presented. After bone marrow transplantation (BMT) from an unrelated donor followed by graft failure and subsequent stimulation by rhu GM-CFC and II-3, this patient experienced complete recovery of autologous haematopoiesis. At 17 months post-BMT the patient was off any therapy with completely normal blood counts and no signs of disease.

摘要

本文报告了一名患青少年慢性粒细胞白血病男孩的不寻常病程。在接受无关供者的骨髓移植(BMT)后发生移植失败,随后用重组人粒细胞巨噬细胞集落刺激因子(rhu GM-CFC)和白细胞介素-3(IL-3)进行刺激,该患者自体造血功能完全恢复。骨髓移植后17个月,患者停止任何治疗,血常规完全正常,无疾病迹象。

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Remission of juvenile chronic myeloid leukemia following graft failure of an unrelated marrow transplant and autologous recovery of marrow function promoted by GM-CSF and IL-3.非亲缘骨髓移植移植失败后,通过粒细胞巨噬细胞集落刺激因子(GM-CSF)和白细胞介素-3(IL-3)促进骨髓功能自体恢复,幼年慢性粒细胞白血病得以缓解。
Leukemia. 1991 Aug;5(8):723-5.
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