Grenader Tal, Isacson Ruth, Reinus Constantin, Rosengarten Ora, Barenholz Orit, Hyman Jordana, Gabizon Alberto, Beller Uzi
Department of Oncology, Sha'are Zedek Medical Center, Jerusalem, Israel.
Onkologie. 2008 Sep;31(8-9):474-6. doi: 10.1159/000142398. Epub 2008 Aug 12.
Primary malignant melanoma of the vagina is extremely rare, accounting for 0.3-0.8% of all malignant melanomas. True amelanotic vaginal melanoma showing no melanin on histological examination is exceedingly rare, accounting for only 2% of all vaginal melanomas.
We describe a 31-year-old female patient who presented with locally advanced amelanotic melanoma of the vagina, with no evidence of metastatic spread on the computerized tomography (CT) scan, but who was subsequently diagnosed as suffering from metastatic disease by positron emission tomography (PET)-CT performed a few weeks following posterior pelvic exenteration.
Specific immunohistochemical staining with melanoma markers should be performed to confirm or exclude a diagnosis of amelanotic melanoma in all patients presenting with a vaginal mass composed of undifferentiated epithelioid malignant cells. Fluorodeoxyglucose (FDG)-PET-CT should be performed as part of the preoperative evaluation, to identify the presence or absence of metastatic disease in all patients with vaginal melanoma.
原发性阴道恶性黑色素瘤极为罕见，占所有恶性黑色素瘤的0.3 - 0.8%。组织学检查无黑色素的真性无色素性阴道黑色素瘤极其罕见，仅占所有阴道黑色素瘤的2%。
我们描述了一名31岁女性患者，其表现为局部晚期无色素性阴道黑色素瘤，计算机断层扫描（CT）未显示转移扩散证据，但在盆腔后脏器清除术后几周进行的正电子发射断层扫描（PET）-CT检查中，随后被诊断为患有转移性疾病。
对于所有表现为由未分化上皮样恶性细胞组成的阴道肿物的患者，应进行黑色素瘤标志物的特异性免疫组化染色，以确诊或排除无色素性黑色素瘤的诊断。氟脱氧葡萄糖（FDG）-PET-CT应作为术前评估的一部分进行，以确定所有阴道黑色素瘤患者是否存在转移性疾病。
