透明边缘变性与双侧角膜穿孔：病例报告及文献综述
Pellucid marginal degeneration and bilateral corneal perforation: case report and review of the literature.
作者信息
Lee William Barry, O'Halloran Henry S, Grossniklaus Hans E
机构信息
Eye Consultants of Atlanta/Piedmont Hospital, 95 Collier Road, Suite 3000, Atlanta, GA 30309, USA.
出版信息
Eye Contact Lens. 2008 Jul;34(4):229-33. doi: 10.1097/ICL.0b013e318164771b.
PURPOSE
To review corneal perforation cases in pellucid marginal degeneration and report a case of bilateral spontaneous perforation at presentation in rigid gas permeable contact lens wear and pellucid marginal degeneration.
METHODS
Case report and literature review.
RESULTS
The presentation, clinical course, surgical intervention, pathologic analysis, and postoperative outcome of a case of bilateral spontaneous corneal perforation in pellucid marginal degeneration are detailed. All spontaneous corneal perforation cases associated with pellucid marginal degeneration are reviewed.
CONCLUSIONS
Pellucid marginal degeneration can lead to spontaneous corneal perforation resulting in the need for urgent therapeutic intervention. A potential for severe ocular morbidity should be considered in all patients with this disorder despite a seemingly stable disease and appropriate gas permeable contact lens wear. Unilateral perforation cases should be watched closely for development of complications in the fellow eye.
目的
回顾透明边缘变性中的角膜穿孔病例，并报告一例在佩戴硬性透气性接触镜及患有透明边缘变性时出现双侧自发性穿孔的病例。
方法
病例报告及文献回顾。
结果
详细阐述了一例透明边缘变性双侧自发性角膜穿孔病例的临床表现、临床病程、手术干预、病理分析及术后结果。对所有与透明边缘变性相关的自发性角膜穿孔病例进行了回顾。
结论
透明边缘变性可导致自发性角膜穿孔，从而需要紧急治疗干预。对于所有患有这种疾病的患者，尽管病情看似稳定且佩戴了合适的透气性接触镜，也应考虑到严重眼部发病的可能性。单侧穿孔病例应密切观察对侧眼并发症的发生情况。
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