Lucarelli M J, Gendelman D S, Talamo J H
Department of Ophthalmology, University of Wisconsin Medical School-Madison, USA.
Cornea. 1997 Mar;16(2):232-4.
Pellucid marginal degeneration of the cornea (1,2) is an idiopathic condition characterized by noninflammatory, nonulcerative thinning of the inferior, peripheral cornea. Occasionally the condition is complicated by acute corneal hydrops (3). We describe a patient with findings suggestive of pellucid marginal corneal degeneration who experienced acute hydrops and spontaneous perforation of the cornea.
A retrospective analysis of the case was conducted.
A 56-year-old woman was seen with decreased vision in the left eye. Clinical findings, including computerized corneal topography, were suggestive of pellucid marginal degeneration. Two weeks later, the patient had hydrops and spontaneous perforation of the left cornea. Medical workup of the patient and histopathologic and microbiologic studies of the corneal specimen revealed no contributory disease process. The patient underwent emergency tectonic lamellar keratoplasty and is doing well after subsequent optical penetrating keratoplasty.
We believe this is the first report of a case of pellucid marginal degeneration of the cornea complicated by hydrops and perforation.
角膜透明边缘变性（1,2）是一种特发性疾病，其特征为下角膜周边部非炎性、非溃疡性变薄。该疾病偶尔会并发急性角膜水肿（3）。我们报告一例疑似角膜透明边缘变性的患者，该患者发生了急性角膜水肿及角膜自发性穿孔。
对该病例进行回顾性分析。
一名56岁女性因左眼视力下降前来就诊。包括电脑角膜地形图在内的临床检查结果提示角膜透明边缘变性。两周后，该患者发生左眼角膜水肿及自发性穿孔。对患者进行的医学检查以及对角膜标本进行的组织病理学和微生物学研究均未发现有促成疾病发生的过程。该患者接受了急诊结构性板层角膜移植术，随后行光学穿透性角膜移植术，术后恢复良好。
我们认为这是首例角膜透明边缘变性并发角膜水肿及穿孔的病例报告。
