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中国乙型肝炎病毒相关肝细胞癌的蛋白质组学分析：一项表面增强激光解吸电离飞行时间质谱研究

Proteomic profiling of hepatitis B virus-related hepatocellular carcinoma in China: a SELDI-TOF-MS study.

作者信息

Zhang Jianzhong, Li Dong, Zheng Yanhua, Cui Yan, Feng Kai, Zhou Jinlian, Wu Jihua

机构信息

Departments of Pathology and Laboratory Medicine, 306 Hospital, Beijing, China.

出版信息

Int J Clin Exp Pathol. 2008 Jan 1;1(4):352-61.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2480544/

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignancies with high mortality, but its underlying molecular mechanisms remain not well understood. High-throughput, proteomic techniques targeting unique biological molecules may provide novel insights into HCC pathogenesis and prognosis. In this study, we systemically investigated tissue biomarkers of HCC by using surface-enhanced laser desorption and ionization time-of-flight mass spectrometry (SELDI-TOF-MS) technique. Proteomic spectra were generated from fresh tissues (26 HCC and 18 control cirrhotic liver) and analyzed by using Biomarker Wizard System. A total of 16 differential proteomic peaks were detected between HCC and cirrhotic liver tissues, and 11 between moderately and highly differentiated HCCs. The expression pattern of one proteomic peak was validated by immunohistochemistry. These molecules are potential candidate biomarkers for early diagnosis of and targeted therapy for HCC.

摘要

肝细胞癌（HCC）是最常见且死亡率高的恶性肿瘤之一，但其潜在分子机制仍未完全明确。针对独特生物分子的高通量蛋白质组学技术可能为HCC的发病机制和预后提供新见解。在本研究中，我们使用表面增强激光解吸电离飞行时间质谱（SELDI-TOF-MS）技术系统地研究了HCC的组织生物标志物。从新鲜组织（26例HCC和18例对照肝硬化肝组织）生成蛋白质组谱，并使用生物标志物向导系统进行分析。在HCC和肝硬化肝组织之间共检测到16个差异蛋白质组峰，在中度和高度分化的HCC之间检测到11个。通过免疫组织化学验证了一个蛋白质组峰的表达模式。这些分子是HCC早期诊断和靶向治疗的潜在候选生物标志物。