Sitwala Kajal V, Dandekar Monisha N, Hess Jay L
Department of Pathology, The University of Michigan Medical School Ann Arbor, Michigan, USA.
Int J Clin Exp Pathol. 2008 Mar 30;1(6):461-74.
HOX and three amino acid loop extension (TALE) proteins cooperate to induce transformation in mouse leukemia models, and are dysregulated in a variety of human leukemias. Despite decades of research, the mechanism of action for Hox proteins in embryogenesis and hematopoiesis remains unclear. Recent studies on the roles of Hoxa9 and Meis1 in leukemia has led to a wealth of new data, but their molecular mechanisms of action and synergy remain obscure. Advances in genome-wide technologies offer new avenues for understanding how homeodomain-containing transcription factors exert their programs in normal and neoplastic development.
HOX蛋白和三氨基酸环延伸（TALE）蛋白在小鼠白血病模型中协同诱导细胞转化，并且在多种人类白血病中表达失调。尽管经过数十年研究，Hox蛋白在胚胎发生和造血过程中的作用机制仍不清楚。最近关于Hoxa9和Meis1在白血病中作用的研究产生了大量新数据，但它们的分子作用机制和协同作用仍不清楚。全基因组技术的进展为理解含同源结构域的转录因子如何在正常和肿瘤发育过程中发挥其调控程序提供了新途径。
