HOX蛋白与白血病。
HOX proteins and leukemia.
作者信息
Sitwala Kajal V, Dandekar Monisha N, Hess Jay L
机构信息
Department of Pathology, The University of Michigan Medical School Ann Arbor, Michigan, USA.
出版信息
Int J Clin Exp Pathol. 2008 Mar 30;1(6):461-74.
Abstract
HOX and three amino acid loop extension (TALE) proteins cooperate to induce transformation in mouse leukemia models, and are dysregulated in a variety of human leukemias. Despite decades of research, the mechanism of action for Hox proteins in embryogenesis and hematopoiesis remains unclear. Recent studies on the roles of Hoxa9 and Meis1 in leukemia has led to a wealth of new data, but their molecular mechanisms of action and synergy remain obscure. Advances in genome-wide technologies offer new avenues for understanding how homeodomain-containing transcription factors exert their programs in normal and neoplastic development.
摘要
HOX蛋白和三氨基酸环延伸（TALE）蛋白在小鼠白血病模型中协同诱导细胞转化，并且在多种人类白血病中表达失调。尽管经过数十年研究，Hox蛋白在胚胎发生和造血过程中的作用机制仍不清楚。最近关于Hoxa9和Meis1在白血病中作用的研究产生了大量新数据，但它们的分子作用机制和协同作用仍不清楚。全基因组技术的进展为理解含同源结构域的转录因子如何在正常和肿瘤发育过程中发挥其调控程序提供了新途径。
相似文献
1
HOX proteins and leukemia.HOX蛋白与白血病。
Int J Clin Exp Pathol. 2008 Mar 30;1(6):461-74.
2
Persistent transactivation by meis1 replaces hox function in myeloid leukemogenesis models: evidence for co-occupancy of meis1-pbx and hox-pbx complexes on promoters of leukemia-associated genes.在髓系白血病发生模型中，meis1的持续反式激活取代了hox功能：meis1-pbx和hox-pbx复合物在白血病相关基因启动子上共同占据的证据。
Mol Cell Biol. 2006 May;26(10):3902-16. doi: 10.1128/MCB.26.10.3902-3916.2006.
3
[Identification of proteins associated with transcription factors HOXA9 and E2A-PBX1 by tandem affinity purification].通过串联亲和纯化鉴定与转录因子HOXA9和E2A-PBX1相关的蛋白质
Mol Biol (Mosk). 2017 May-Jun;51(3):490-501. doi: 10.7868/S0026898417030132.
4
Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia.确定HOX和MEIS1基因在急性髓系白血病诱导中的作用。
Mol Cell Biol. 2001 Jan;21(1):224-34. doi: 10.1128/MCB.21.1.224-234.2001.
5
C-terminal domain of MEIS1 converts PKNOX1 (PREP1) into a HOXA9-collaborating oncoprotein.MEIS1 的 C 末端结构域将 PKNOX1（PREP1）转化为 HOXA9 协作癌蛋白。
Blood. 2011 Oct 27;118(17):4682-9. doi: 10.1182/blood-2011-05-354076. Epub 2011 Sep 7.
6
AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins.AbdB 样同源框蛋白可稳定 Meis1 同源结构域蛋白与 DNA 的结合。
Mol Cell Biol. 1997 Nov;17(11):6448-58. doi: 10.1128/MCB.17.11.6448.
7
PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease.PBX3和MEIS1在造血细胞中协同作用，驱动以MLL重排疾病核心转录组为特征的急性髓系白血病。
Cancer Res. 2016 Feb 1;76(3):619-29. doi: 10.1158/0008-5472.CAN-15-1566. Epub 2016 Jan 8.
8
Pbx3 and Meis1 cooperate through multiple mechanisms to support Hox-induced murine leukemia.Pbx3和Meis1通过多种机制协同作用，以支持Hox诱导的小鼠白血病。
Haematologica. 2015 Jul;100(7):905-13. doi: 10.3324/haematol.2015.124032. Epub 2015 Apr 24.
9
Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3.Meis1 的强大白血病发生活性与细胞周期进入和细胞周期蛋白 D3 的转录调节相关联。
Blood. 2010 May 20;115(20):4071-82. doi: 10.1182/blood-2009-06-225573. Epub 2010 Mar 17.
10
Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human myeloid leukemias.HOXA9和MEIS1同源盒基因在人类髓系白血病中频繁共表达。
Leukemia. 1999 Dec;13(12):1993-9. doi: 10.1038/sj.leu.2401578.
引用本文的文献
1
Genetic and phenotypic continuum of HOXA genes: A case with double HOXA9/HOXA13 mutations.HOXA 基因的遗传和表型连续体：一例 HOXA9/HOXA13 双突变。
Mol Med Rep. 2023 Mar;27(3). doi: 10.3892/mmr.2023.12946. Epub 2023 Feb 3.
2
A novel fatty acid metabolism-related signature identifies features of the tumor microenvironment and predicts clinical outcome in acute myeloid leukemia.一种新型脂肪酸代谢相关特征可识别急性髓系白血病肿瘤微环境的特征，并预测临床结局。
Lipids Health Dis. 2022 Aug 25;21(1):79. doi: 10.1186/s12944-022-01687-x.
3
The Historical Relationship Between Meis1 and Leukemia.Meis1 与白血病的历史关系。
Adv Exp Med Biol. 2022;1387:127-144. doi: 10.1007/5584_2021_705.
4
Histone H3K36me2-Specific Methyltransferase ASH1L Promotes MLL-AF9-Induced Leukemogenesis.组蛋白H3K36me2特异性甲基转移酶ASH1L促进MLL-AF9诱导的白血病发生。
Front Oncol. 2021 Oct 8;11:754093. doi: 10.3389/fonc.2021.754093. eCollection 2021.
5
Oncogenic and tumor suppressor function of MEIS and associated factors.MEIS及相关因子的致癌和抑癌功能。
Turk J Biol. 2020 Dec 14;44(6):328-355. doi: 10.3906/biy-2006-25. eCollection 2020.
6
Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor.使用聚焦 DNA 编码文库优化配体，开发选择性、细胞渗透性 CBX8 染色质结构域抑制剂。
ACS Chem Biol. 2020 Jan 17;15(1):112-131. doi: 10.1021/acschembio.9b00654. Epub 2019 Dec 12.
7
Activity-Dependent Regulation of the Proapoptotic BH3-Only Gene in a Living Neuron Pair in .在活体神经元对中，依赖于活性的促凋亡 BH3-Only 基因的调节。
G3 (Bethesda). 2019 Nov 5;9(11):3703-3714. doi: 10.1534/g3.119.400654.
8
MicroRNA-182 downregulates Wnt/β-catenin signaling, inhibits proliferation, and promotes apoptosis in human osteosarcoma cells by targeting HOXA9.微小RNA-182通过靶向HOXA9下调Wnt/β-连环蛋白信号通路，抑制人骨肉瘤细胞增殖并促进其凋亡。
Oncotarget. 2017 Sep 22;8(60):101345-101361. doi: 10.18632/oncotarget.21167. eCollection 2017 Nov 24.
9
Taking a Bad Turn: Compromised DNA Damage Response in Leukemia.病情恶化：白血病中受损的DNA损伤反应
Cells. 2017 May 4;6(2):11. doi: 10.3390/cells6020011.
10
Role of MAML1 and MEIS1 in Esophageal Squamous Cell Carcinoma Depth of Invasion.MAML1和MEIS1在食管鳞状细胞癌浸润深度中的作用。
Pathol Oncol Res. 2018 Apr;24(2):245-250. doi: 10.1007/s12253-017-0243-1. Epub 2017 May 1.
本文引用的文献
1
HoxA9 induces insulin-like growth factor-1 receptor expression in B-lineage acute lymphoblastic leukemia.HoxA9在B系急性淋巴细胞白血病中诱导胰岛素样生长因子-1受体表达。
Leukemia. 2008 Jun;22(6):1161-9. doi: 10.1038/leu.2008.57. Epub 2008 Mar 13.
2
Review: genetic models of acute myeloid leukaemia.综述：急性髓系白血病的遗传模型
Oncogene. 2008 Jun 19;27(27):3765-79. doi: 10.1038/onc.2008.16. Epub 2008 Feb 11.
3
T cell receptor genotyping and HOXA/TLX1 expression define three T lymphoblastic lymphoma subsets which might affect clinical outcome.T细胞受体基因分型和HOXA/TLX1表达可界定三个T淋巴母细胞淋巴瘤亚组，这可能会影响临床结局。
Clin Cancer Res. 2008 Feb 1;14(3):692-700. doi: 10.1158/1078-0432.CCR-07-1927.
4
Three-dimensional intricacies in protein-DNA recognition and transcriptional control.蛋白质-DNA识别与转录调控中的三维复杂性。
Nat Struct Mol Biol. 2007 Dec;14(12):1118-9. doi: 10.1038/nsmb1207-1118.
5
PBX proteins: much more than Hox cofactors.PBX蛋白：远不止是Hox辅因子。
Int J Dev Biol. 2008;52(1):9-20. doi: 10.1387/ijdb.072304al.
6
MEIS and PBX homeobox proteins in ovarian cancer.卵巢癌中的MEIS和PBX同源盒蛋白
Eur J Cancer. 2007 Nov;43(17):2495-505. doi: 10.1016/j.ejca.2007.08.025. Epub 2007 Oct 18.
7
Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.Meis1是MLL白血病干细胞潜能的关键且限速调节因子。
Genes Dev. 2007 Nov 1;21(21):2762-74. doi: 10.1101/gad.1602107. Epub 2007 Oct 17.
8
Hox genes in hematopoiesis and leukemogenesis.造血作用和白血病发生过程中的Hox基因
Oncogene. 2007 Oct 15;26(47):6766-76. doi: 10.1038/sj.onc.1210760.
9
Mixed lineage leukemia translocations and a leukemia stem cell program.混合谱系白血病易位与白血病干细胞程序。
Cancer Res. 2007 Sep 15;67(18):8425-8. doi: 10.1158/0008-5472.CAN-07-0972.
10
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.不宁腿综合征的全基因组关联研究确定了三个基因组区域中的常见变异。
Nat Genet. 2007 Aug;39(8):1000-6. doi: 10.1038/ng2099. Epub 2007 Jul 18.
Zotero 插件