HOX蛋白与白血病。
HOX proteins and leukemia.
作者信息
Sitwala Kajal V, Dandekar Monisha N, Hess Jay L
机构信息
Department of Pathology, The University of Michigan Medical School Ann Arbor, Michigan, USA.
出版信息
Int J Clin Exp Pathol. 2008 Mar 30;1(6):461-74.
Abstract
HOX and three amino acid loop extension (TALE) proteins cooperate to induce transformation in mouse leukemia models, and are dysregulated in a variety of human leukemias. Despite decades of research, the mechanism of action for Hox proteins in embryogenesis and hematopoiesis remains unclear. Recent studies on the roles of Hoxa9 and Meis1 in leukemia has led to a wealth of new data, but their molecular mechanisms of action and synergy remain obscure. Advances in genome-wide technologies offer new avenues for understanding how homeodomain-containing transcription factors exert their programs in normal and neoplastic development.
摘要
HOX蛋白和三氨基酸环延伸（TALE）蛋白在小鼠白血病模型中协同诱导细胞转化，并且在多种人类白血病中表达失调。尽管经过数十年研究，Hox蛋白在胚胎发生和造血过程中的作用机制仍不清楚。最近关于Hoxa9和Meis1在白血病中作用的研究产生了大量新数据，但它们的分子作用机制和协同作用仍不清楚。全基因组技术的进展为理解含同源结构域的转录因子如何在正常和肿瘤发育过程中发挥其调控程序提供了新途径。
相似文献
1
HOX proteins and leukemia.
Int J Clin Exp Pathol. 2008 Mar 30;1(6):461-74.
2
Persistent transactivation by meis1 replaces hox function in myeloid leukemogenesis models: evidence for co-occupancy of meis1-pbx and hox-pbx complexes on promoters of leukemia-associated genes.
Mol Cell Biol. 2006 May;26(10):3902-16. doi: 10.1128/MCB.26.10.3902-3916.2006.
3
[Identification of proteins associated with transcription factors HOXA9 and E2A-PBX1 by tandem affinity purification].
Mol Biol (Mosk). 2017 May-Jun;51(3):490-501. doi: 10.7868/S0026898417030132.
4
Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia.
Mol Cell Biol. 2001 Jan;21(1):224-34. doi: 10.1128/MCB.21.1.224-234.2001.
5
C-terminal domain of MEIS1 converts PKNOX1 (PREP1) into a HOXA9-collaborating oncoprotein.
Blood. 2011 Oct 27;118(17):4682-9. doi: 10.1182/blood-2011-05-354076. Epub 2011 Sep 7.
6
AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins.
Mol Cell Biol. 1997 Nov;17(11):6448-58. doi: 10.1128/MCB.17.11.6448.
7
PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease.
Cancer Res. 2016 Feb 1;76(3):619-29. doi: 10.1158/0008-5472.CAN-15-1566. Epub 2016 Jan 8.
8
Pbx3 and Meis1 cooperate through multiple mechanisms to support Hox-induced murine leukemia.
Haematologica. 2015 Jul;100(7):905-13. doi: 10.3324/haematol.2015.124032. Epub 2015 Apr 24.
9
Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3.
Blood. 2010 May 20;115(20):4071-82. doi: 10.1182/blood-2009-06-225573. Epub 2010 Mar 17.
10
Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human myeloid leukemias.
Leukemia. 1999 Dec;13(12):1993-9. doi: 10.1038/sj.leu.2401578.
引用本文的文献
1
Genetic and phenotypic continuum of HOXA genes: A case with double HOXA9/HOXA13 mutations.
Mol Med Rep. 2023 Mar;27(3). doi: 10.3892/mmr.2023.12946. Epub 2023 Feb 3.
2
A novel fatty acid metabolism-related signature identifies features of the tumor microenvironment and predicts clinical outcome in acute myeloid leukemia.
Lipids Health Dis. 2022 Aug 25;21(1):79. doi: 10.1186/s12944-022-01687-x.
3
The Historical Relationship Between Meis1 and Leukemia.
Adv Exp Med Biol. 2022;1387:127-144. doi: 10.1007/5584_2021_705.
4
Histone H3K36me2-Specific Methyltransferase ASH1L Promotes MLL-AF9-Induced Leukemogenesis.
Front Oncol. 2021 Oct 8;11:754093. doi: 10.3389/fonc.2021.754093. eCollection 2021.
5
Oncogenic and tumor suppressor function of MEIS and associated factors.
Turk J Biol. 2020 Dec 14;44(6):328-355. doi: 10.3906/biy-2006-25. eCollection 2020.
6
Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor.
ACS Chem Biol. 2020 Jan 17;15(1):112-131. doi: 10.1021/acschembio.9b00654. Epub 2019 Dec 12.
7
Activity-Dependent Regulation of the Proapoptotic BH3-Only Gene in a Living Neuron Pair in .
G3 (Bethesda). 2019 Nov 5;9(11):3703-3714. doi: 10.1534/g3.119.400654.
8
MicroRNA-182 downregulates Wnt/β-catenin signaling, inhibits proliferation, and promotes apoptosis in human osteosarcoma cells by targeting HOXA9.
Oncotarget. 2017 Sep 22;8(60):101345-101361. doi: 10.18632/oncotarget.21167. eCollection 2017 Nov 24.
9
Taking a Bad Turn: Compromised DNA Damage Response in Leukemia.
Cells. 2017 May 4;6(2):11. doi: 10.3390/cells6020011.
10
Role of MAML1 and MEIS1 in Esophageal Squamous Cell Carcinoma Depth of Invasion.
Pathol Oncol Res. 2018 Apr;24(2):245-250. doi: 10.1007/s12253-017-0243-1. Epub 2017 May 1.
本文引用的文献
1
HoxA9 induces insulin-like growth factor-1 receptor expression in B-lineage acute lymphoblastic leukemia.
Leukemia. 2008 Jun;22(6):1161-9. doi: 10.1038/leu.2008.57. Epub 2008 Mar 13.
2
Review: genetic models of acute myeloid leukaemia.
Oncogene. 2008 Jun 19;27(27):3765-79. doi: 10.1038/onc.2008.16. Epub 2008 Feb 11.
3
T cell receptor genotyping and HOXA/TLX1 expression define three T lymphoblastic lymphoma subsets which might affect clinical outcome.
Clin Cancer Res. 2008 Feb 1;14(3):692-700. doi: 10.1158/1078-0432.CCR-07-1927.
4
Three-dimensional intricacies in protein-DNA recognition and transcriptional control.
Nat Struct Mol Biol. 2007 Dec;14(12):1118-9. doi: 10.1038/nsmb1207-1118.
5
PBX proteins: much more than Hox cofactors.
Int J Dev Biol. 2008;52(1):9-20. doi: 10.1387/ijdb.072304al.
6
MEIS and PBX homeobox proteins in ovarian cancer.
Eur J Cancer. 2007 Nov;43(17):2495-505. doi: 10.1016/j.ejca.2007.08.025. Epub 2007 Oct 18.
7
Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.
Genes Dev. 2007 Nov 1;21(21):2762-74. doi: 10.1101/gad.1602107. Epub 2007 Oct 17.
8
Hox genes in hematopoiesis and leukemogenesis.
Oncogene. 2007 Oct 15;26(47):6766-76. doi: 10.1038/sj.onc.1210760.
9
Mixed lineage leukemia translocations and a leukemia stem cell program.
Cancer Res. 2007 Sep 15;67(18):8425-8. doi: 10.1158/0008-5472.CAN-07-0972.
10
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.
Nat Genet. 2007 Aug;39(8):1000-6. doi: 10.1038/ng2099. Epub 2007 Jul 18.
Zotero 插件