Faber Joerg, Armstrong Scott A
Division of Hematology/Oncology, Children's Hospital, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
Cancer Res. 2007 Sep 15;67(18):8425-8. doi: 10.1158/0008-5472.CAN-07-0972.
Cancer stem cells (CSC) may provide the self-renewal capacity required to sustain a tumor. One possibility is that CSC arise from the stem cell counterparts in normal tissues. Alternatively, CSC may arise from more differentiated progenitor cells found in certain tissues. In support of this idea, we showed recently that mixed lineage leukemia fusion oncoproteins can convert committed hematopoietic progenitors into leukemias, which include leukemia stem cells expressing a self-renewal associated program in the context of a differentiated myeloid cell. The findings suggest a basis to understand the pathobiology of CSC and possible strategies to attack them to undermine the self-renewal capacity of a tumor.
癌症干细胞（CSC）可能提供维持肿瘤所需的自我更新能力。一种可能性是CSC源自正常组织中的干细胞对应物。或者，CSC可能源自某些组织中更分化的祖细胞。支持这一观点的是，我们最近发现混合谱系白血病融合癌蛋白可将定向造血祖细胞转化为白血病，其中包括在分化的髓样细胞背景下表达自我更新相关程序的白血病干细胞。这些发现为理解CSC的病理生物学以及攻击它们以破坏肿瘤自我更新能力的可能策略提供了基础。
