De Palma Giuseppe, Mariotti Orietta, Lonati Davide, Goldoni Matteo, Catalani Simona, Mutti Antonio, Locatelli Carlo, Apostoli Pietro
Department of Experimental and Applied Medicine, Section of Industrial Hygiene, University of Brescia, Brescia, Italy.
Clin Toxicol (Phila). 2008 Nov;46(9):869-76. doi: 10.1080/15563650802136241.
Intravenous injection of mercury has seldom been reported, especially in cases of attempted suicide, and is associated with variable clinical outcomes.
A young woman came to our attention after self-injecting and ingesting mercury drawn from 37 thermometers. The patient suffered lung embolization complicated by adult respiratory distress syndrome (ARDS), toxic dermatitis, anemia, mild hepato-renal impairment, and died after 30 days. Mercury was monitored in biological fluids (blood, plasma, urine, and bronchoalveolar fluid) to study its toxicokinetics and to evaluate dose-effect relationships. Its urinary clearance significantly increased after a chelation challenge test with meso-2,3-dimercaptosuccinic acid (DMSA) (median values of 2.48 and 8.85 before and after the test, respectively, p < 0.05).
Mercury poisoning by intravenous injection is a clinical emergency, potentially leading to death. When injected, the element has a very slow clearance, mainly renal. Our data do not allow any conclusion about the effectiveness of chelation therapy.
静脉注射汞的情况鲜有报道，尤其是在自杀未遂案例中，其临床结局各异。
一名年轻女性在自行注射并吞食从37支体温计中获取的汞后引起我们的注意。该患者发生肺栓塞并并发成人呼吸窘迫综合征（ARDS）、中毒性皮炎、贫血、轻度肝肾损害，30天后死亡。对生物体液（血液、血浆、尿液和支气管肺泡灌洗液）中的汞进行监测，以研究其毒代动力学并评估剂量-效应关系。在用内消旋-2,3-二巯基丁二酸（DMSA）进行螯合激发试验后，其尿清除率显著增加（试验前后的中位数分别为2.48和8.85，p<0.05）。
静脉注射汞中毒是一种临床急症，可能导致死亡。注射后，该元素清除缓慢，主要通过肾脏清除。我们的数据无法就螯合疗法的有效性得出任何结论。
