局灶性脑缺血后用LXR激动剂治疗可预防脑损伤。
Treatment with LXR agonists after focal cerebral ischemia prevents brain damage.
作者信息
Sironi Luigi, Mitro Nico, Cimino Mauro, Gelosa Paolo, Guerrini Uliano, Tremoli Elena, Saez Enrique
机构信息
Department of Pharmacological Sciences, University of Milan,Via G. Balzaretti 9, 20133 Milan, Italy.
出版信息
FEBS Lett. 2008 Oct 15;582(23-24):3396-400. doi: 10.1016/j.febslet.2008.08.035. Epub 2008 Sep 19.
Abstract
Stroke is characterized by massive inflammation in areas surrounding the injury that magnifies damage to the brain. The liver X receptors (LXRs) are nuclear receptors that regulate cholesterol, lipid, and glucose metabolism. Synthetic LXR agonists have potent anti-inflammatory properties in a variety of settings, including neuroinflammation. However, the ability of LXR agonists to suppress stroke-associated inflammation has not been evaluated. Here, we have used time-lapse magnetic resonance imaging (MRI) to show that a single dose of an LXR ligand administered post-injury dramatically reduces brain damage in a model of acute brain ischemia. Neuroprotection was associated with suppression of neuroinflammation.
摘要
中风的特征是损伤周围区域出现大量炎症，这会加剧对大脑的损害。肝脏X受体（LXRs）是调节胆固醇、脂质和葡萄糖代谢的核受体。合成的LXR激动剂在包括神经炎症在内的多种情况下具有强大的抗炎特性。然而，LXR激动剂抑制中风相关炎症的能力尚未得到评估。在这里，我们使用延时磁共振成像（MRI）表明，在急性脑缺血模型中，损伤后给予单剂量的LXR配体可显著减少脑损伤。神经保护作用与神经炎症的抑制有关。
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