Thomas Dow C
Department of Ophthalmology, University of Wisconsin, Madison, WI 53792, USA.
Med Hypotheses. 2008 Dec;71(6):858-61. doi: 10.1016/j.mehy.2008.07.036. Epub 2008 Sep 11.
The plausibility of a causal role of Mycobacterium avium subspecies paratuberculosis (MAP) in Crohn's disease has gone from controversial to compelling. This century old debate is resolving because of unfolding understanding of shared genetic susceptibilities for Crohn's and mycobacterial infection in addition to newer laboratory tests to detect MAP which have linked MAP and Crohn's. Mycobacterial heat shock proteins are associated with a multitude of "autoimmune" diseases, including Type 1 diabetes mellitus (T1DM) and the initiating events of atherosclerosis. These heat shock proteins may come from MAP; this article postulates a causal role for MAP in multiple inflammatory and "autoimmune" diseases.
鸟分枝杆菌副结核亚种（MAP）在克罗恩病中具有因果作用这一观点，其可信度已从有争议变为令人信服。这场持续了一个世纪的争论正在得到解决，这是因为人们对克罗恩病和分枝杆菌感染的共同遗传易感性有了进一步的认识，此外，检测MAP的新实验室检测方法也将MAP与克罗恩病联系了起来。分枝杆菌热休克蛋白与多种“自身免疫性”疾病相关，包括1型糖尿病（T1DM）和动脉粥样硬化的起始事件。这些热休克蛋白可能来自MAP；本文假定MAP在多种炎症性和“自身免疫性”疾病中具有因果作用。
