痘苗病毒的形态发生与传播。

Vaccinia virus morphogenesis and dissemination.

作者信息

Roberts Kim L, Smith Geoffrey L

机构信息

Department of Virology, Faculty of Medicine, Imperial College London, St. Mary's Campus, Norfolk Place, London, W2 1PG, UK.

出版信息

Trends Microbiol. 2008 Oct;16(10):472-9. doi: 10.1016/j.tim.2008.07.009. Epub 2008 Sep 12.

DOI:10.1016/j.tim.2008.07.009

PMID:18789694

Abstract

Vaccinia virus is the smallpox vaccine. It is the most intensively studied poxvirus, and its study has provided important insights about virus replication in general and the interactions of viruses with the host cell and immune system. Here, the entry, morphogenesis and dissemination of vaccinia virus are considered. These processes are complicated by the existence of two infectious vaccinia virus particles, called intracellular mature virus (IMV) and extracellular enveloped virus (EEV). The IMV particle is surrounded by one membrane, and the EEV particle comprises an IMV particle enclosed within a second lipid membrane containing several viral antigens. Consequently, these virions have different biological properties and play different roles in the virus life cycle.

摘要

痘苗病毒就是天花疫苗。它是研究最为深入的痘病毒，对它的研究为全面了解病毒复制以及病毒与宿主细胞和免疫系统的相互作用提供了重要见解。在此，我们将探讨痘苗病毒的进入、形态发生和传播过程。由于存在两种具有感染性的痘苗病毒颗粒，即细胞内成熟病毒（IMV）和细胞外被膜病毒（EEV），这些过程变得复杂起来。IMV颗粒被一层膜包围，而EEV颗粒则由一个被包含多种病毒抗原的第二层脂质膜包裹的IMV颗粒组成。因此，这些病毒粒子具有不同的生物学特性，在病毒生命周期中发挥着不同的作用。