Yaturu Subhashini, Rains Justin, Jain Sushil K
Department of Endocrinology, Overton Brooks VA Medical Center/LSUHSC, 510 East Stoner Avenue, 111E, Shreveport, LA 71101-4295, USA.
Cytokine. 2008 Oct;44(1):168-71. doi: 10.1016/j.cyto.2008.07.471. Epub 2008 Sep 11.
Our objective of this study is to investigate the relationship between plasma osteoprotegerin (OPG) levels in type 2 diabetes and its relationship with the insulin resistance, HbA(1c), CRP, and TNF-alpha levels.
In a cross-sectional study, levels of OPG were determined in 50 subjects with type 2 diabetes and 59 control subjects without diabetes. The OPG levels between the groups were compared and their correlation with insulin resistance, glycemia and inflammatory markers CRP and TNF-alpha was determined.
OPG levels were elevated in subjects with diabetes (6.8+/-0.27 pmol/l), compared to control subjects (5.7+/-0.26 pmol/l). OPG levels significantly correlate with insulin, insulin resistance, CRP, and TNF-alpha.
OPG levels are significantly correlated with insulin resistance and may reflect the proinflammatory state in type 2 diabetes.
本研究的目的是调查2型糖尿病患者血浆骨保护素（OPG）水平及其与胰岛素抵抗、糖化血红蛋白（HbA1c）、C反应蛋白（CRP）和肿瘤坏死因子-α（TNF-α）水平的关系。
在一项横断面研究中，测定了50例2型糖尿病患者和59例无糖尿病对照者的OPG水平。比较了两组之间的OPG水平，并确定了其与胰岛素抵抗、血糖以及炎症标志物CRP和TNF-α的相关性。
与对照者（5.7±0.26 pmol/l）相比，糖尿病患者的OPG水平升高（6.8±0.27 pmol/l）。OPG水平与胰岛素、胰岛素抵抗、CRP和TNF-α显著相关。
OPG水平与胰岛素抵抗显著相关，可能反映了2型糖尿病的促炎状态。
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