Bilgir Oktay, Yavuz Mehmet, Bilgir Ferda, Akan Ozden Y, Bayindir Aslı G, Calan Mehmet, Bozkaya Giray, Yuksel Arif
Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, Bozyaka, Izmir, Turkey -
Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, Bozyaka, Izmir, Turkey.
Minerva Endocrinol. 2018 Mar;43(1):19-26. doi: 10.23736/S0391-1977.17.02544-5. Epub 2017 Jan 31.
Receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPN) are soluble members of the tumor necrosis factor superfamily. Growing evidence suggest that there is link between inflammation, insulin resistance and OPG, soluble RANKL (sRANKL). We aimed to ascertain whether OPG and sRANKL levels are altered in prediabetic subjects and there is association between OPG/sRANKL and metabolic parameters.
Forty prediabetic subjects and 40 age- and BMI-matched controls were recruited for this cross-sectional study. Circulating OPG, sRANKL were measured using ELISA. Anthropometric and metabolic parameters were also determined.
Circulating sRANKL (97.74±17.67 vs. 55.00±11.19 pg/mL, P=0.010) and OPG (261.54±74.55 vs. 159.23±52.91 pg/mL, P=0.020) levels were found to be significantly higher in diabetic subjects compared with control subjects. There was a positive correlation between sRANKL and OPG. sRANKL also positively correlated with BMI, insulin resistance marker HOMA-IR, inflammatory marker hs-CRP. Logistic regression analyses revealed that the odds ratio was increased for prediabetes in subjects with having elevated sRANKL levels.
Increased sRANKL and OPG levels were associated with prediabetic subjects. sRANKL and OPG may play a role in the pathogenesis of diabetes as well as metabolic disturbance.
核因子κB受体激活剂配体（RANKL）和骨保护素（OPG）是肿瘤坏死因子超家族的可溶性成员。越来越多的证据表明，炎症、胰岛素抵抗与OPG、可溶性RANKL（sRANKL）之间存在联系。我们旨在确定糖尿病前期患者的OPG和sRANKL水平是否发生改变，以及OPG/sRANKL与代谢参数之间是否存在关联。
本横断面研究招募了40名糖尿病前期患者和40名年龄及体重指数匹配的对照者。采用酶联免疫吸附测定法检测循环中的OPG、sRANKL。还测定了人体测量和代谢参数。
发现糖尿病前期患者的循环sRANKL水平（97.74±17.67 vs. 55.00±11.19 pg/mL，P = 0.010）和OPG水平（261.54±74.55 vs. 159.23±52.91 pg/mL，P = 0.020）显著高于对照者。sRANKL与OPG呈正相关。sRANKL还与体重指数、胰岛素抵抗标志物HOMA-IR、炎症标志物hs-CRP呈正相关。逻辑回归分析显示，sRANKL水平升高的受试者患糖尿病前期的比值比增加。
sRANKL和OPG水平升高与糖尿病前期患者相关。sRANKL和OPG可能在糖尿病发病机制以及代谢紊乱中起作用。
