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2型糖尿病患者调节性T细胞及促炎和免疫抑制细胞因子的变化：一项系统评价和荟萃分析

Changes of Regulatory T Cells and of Proinflammatory and Immunosuppressive Cytokines in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

作者信息

Qiao Yong-Chao, Shen Jian, He Lan, Hong Xue-Zhi, Tian Fang, Pan Yan-Hong, Liang Ling, Zhang Xiao-Xi, Zhao Hai-Lu

机构信息

Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China; Department of Immunology, School of Basic Medical Sciences, Central South University, Changsha, Hunan 410078, China.

Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence, Guilin Medical University, Guilin 541004, China.

出版信息

J Diabetes Res. 2016;2016:3694957. doi: 10.1155/2016/3694957. Epub 2016 Sep 29.

DOI:10.1155/2016/3694957
PMID:27777959
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5061980/
Abstract

. The aim of this study was to investigate the changes of regulatory T cells (Treg), interleukin-6 (IL-6), IL-10, transforming growth factor- (TGF-), and tumor necrosis factor-alpha (TNF-) in patients with type 2 diabetes mellitus (T2DM). . We performed a comprehensive search up to July 2016 for all clinical studies about the changes of Treg, IL-6, IL-10, IL-17, TGF-, and TNF- in T2DM patients versus healthy controls. . A total of 91 articles (5642 cases and 7378 controls) were included for this meta-analysis. Compared with the controls (all < 0.001), the patients had increased serum levels of IL-6, TGF-, and TNF- but decreased the percentage of peripheral CD4CD25Foxp3Treg and serum IL-10 level. Furthermore, the percentage of peripheral CD4CD25Foxp3Treg ( < 0.001) and serum IL-10 level ( = 0.033) were significantly lower in the patients with complication and in the patients without complication, respectively. No significant changes about the percentage of CD4CD25Treg ( = 0.360) and serum IL-17 level ( = 0.459) were found in T2DM patients. . T2DM patients have decreased the percentage of peripheral CD4CD25Foxp3Treg and levels of serum IL-10 but elevated serum levels of IL-6, TGF-, and TNF-. Presence of diabetic complications further lowers the peripheral CD4CD25Foxp3Treg number.

摘要

本研究旨在探讨2型糖尿病（T2DM）患者体内调节性T细胞（Treg）、白细胞介素-6（IL-6）、IL-10、转化生长因子-（TGF-）和肿瘤坏死因子-α（TNF-）的变化情况。我们全面检索了截至2016年7月的所有关于T2DM患者与健康对照者体内Treg、IL-6、IL-10、IL-17、TGF-和TNF-变化的临床研究。本荟萃分析共纳入91篇文章（5642例患者和7378例对照）。与对照组相比（所有P<0.001），患者血清IL-6、TGF-和TNF-水平升高，但外周血CD4⁺CD25⁺Foxp3⁺Treg百分比及血清IL-10水平降低。此外，有并发症患者的外周血CD4⁺CD25⁺Foxp3⁺Treg百分比（P<0.001）和无并发症患者的血清IL-10水平（P = 0.033）分别显著降低。T2DM患者的CD4⁺CD25⁺Treg百分比（P = 0.360）和血清IL-17水平（P = 0.459）未发现显著变化。T2DM患者外周血CD4⁺CD25⁺Foxp3⁺Treg百分比及血清IL-10水平降低，但血清IL-6、TGF-和TNF-水平升高。糖尿病并发症的存在进一步降低外周血CD4⁺CD25⁺Foxp3⁺Treg数量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3440/5061980/a01c341a2b37/JDR2016-3694957.009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3440/5061980/9793dafec7de/JDR2016-3694957.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3440/5061980/01808f946389/JDR2016-3694957.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3440/5061980/292dad684193/JDR2016-3694957.003.jpg
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