Lind M J, Murphy D J, Sharma H, Tinker N, Smith A, McAuliffe C A, Crowther D
CRC Department of Medical Oncology, Christie Hospital, Manchester, UK.
Cancer Chemother Pharmacol. 1991;28(4):315-7. doi: 10.1007/BF00685543.
The pharmakokinetic profiles of intraperitoneally infused platinum analogues were determined in 13 women exhibiting minimal residual disease following surgery and systemic chemotherapy for epithelial ovarian cancer or fallopian tube carcinoma by following the disposition of tracer doses of 195mPt radiolabel. Six patients received iproplatin, four were given cisplatin and three received carboplatin. The present data demonstrate no difference in the disposition of total platinum between these three analogues, but differences in the kinetics of free platinum may exist.
通过追踪示踪剂量的195mPt放射性标记物的处置情况，在13名接受上皮性卵巢癌或输卵管癌手术及全身化疗后残留疾病最少的女性中，测定了腹腔内注入铂类类似物的药代动力学特征。6名患者接受了异丙铂，4名接受了顺铂，3名接受了卡铂。目前的数据表明，这三种类似物之间总铂的处置没有差异，但游离铂的动力学可能存在差异。
