Calabrese Vittorio, Bates Timothy E, Mancuso Cesare, Cornelius Carolin, Ventimiglia Bernardo, Cambria Maria Teresa, Di Renzo Laura, De Lorenzo Antonino, Dinkova-Kostova Albena T
Department of Chemistry, Clinical Biochemistry and Clinical Molecular Biology Chair, University of Catania, Catania, Italy.
Mol Nutr Food Res. 2008 Sep;52(9):1062-73. doi: 10.1002/mnfr.200700316.
Free radicals play a main pathogenic role in several human diseases such as neurodegenerative disorders, diabetes, and cancer. Although there has been progress in treatment of these diseases, the development of important side effects may complicate the therapeutic course. Curcumin, a well known spice commonly used in India to make foods colored and flavored, is also used in traditional medicine to treat mild or moderate human diseases. In the recent years, a growing body of literature has unraveled the antioxidant, anticarcinogenic, and antinfectious activity of curcumin based on the ability of this compound to regulate a number of cellular signal transduction pathways. These promising data obtained in vitro are now being translated to the clinic and more than ten clinical trials are currently ongoing worldwide. This review outlines the biological activities of curcumin and discusses its potential use in the prevention and treatment of human diseases.
自由基在多种人类疾病中发挥主要致病作用，如神经退行性疾病、糖尿病和癌症。尽管这些疾病的治疗已取得进展，但重要副作用的出现可能使治疗过程复杂化。姜黄素是印度常用的一种著名香料，用于使食物上色和调味，在传统医学中也用于治疗轻度或中度人类疾病。近年来，越来越多的文献揭示了姜黄素的抗氧化、抗癌和抗感染活性，这基于该化合物调节多种细胞信号转导途径的能力。这些在体外获得的有前景的数据目前正在转化为临床应用，全球范围内目前有十多项临床试验正在进行。本综述概述了姜黄素的生物学活性，并讨论了其在预防和治疗人类疾病中的潜在用途。
