E盒蛋白E2-2是浆细胞样树突状细胞发育的关键调节因子。
E-box protein E2-2 is a crucial regulator of plasmacytoid DC development.
作者信息
Esashi Eiji, Liu Yong-Jun
机构信息
Department of Immunology and Center for Cancer Immunology Research, University of Texas, M. D. Anderson Cancer Center, Houston, TX 77030, USA.
出版信息
Eur J Immunol. 2008 Sep;38(9):2386-8. doi: 10.1002/eji.200838763.
Abstract
DC play central roles in priming both innate and adaptive immune responses. Multiple DC subsets have been identified on the basis of their phenotype and function. Plasmacytoid DC (pDC) are professional IFN-producing cells that play an essential role in anti-viral immunity. A series of recent studies demonstrates that the regulation of pDC development is different from other types of DC. In this issue of the European Journal of Immunology, new insight is provided into how human pDC development is regulated by various transcription factors, in particular by the Ets family protein Spi-B and E-box protein E2-2.
摘要
树突状细胞（DC）在启动先天性和适应性免疫反应中发挥核心作用。基于其表型和功能已鉴定出多个DC亚群。浆细胞样DC（pDC）是产生干扰素的专职细胞，在抗病毒免疫中起重要作用。最近的一系列研究表明，pDC发育的调控不同于其他类型的DC。在本期《欧洲免疫学杂志》中，我们对人类pDC发育如何受到各种转录因子，特别是Ets家族蛋白Spi-B和E-box蛋白E2-2的调控有了新的认识。
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