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E-box protein E2-2 is a crucial regulator of plasmacytoid DC development.E盒蛋白E2-2是浆细胞样树突状细胞发育的关键调节因子。
Eur J Immunol. 2008 Sep;38(9):2386-8. doi: 10.1002/eji.200838763.
2
Development of human plasmacytoid dendritic cells depends on the combined action of the basic helix-loop-helix factor E2-2 and the Ets factor Spi-B.人类浆细胞样树突状细胞的发育依赖于碱性螺旋-环-螺旋因子E2-2和Ets因子Spi-B的联合作用。
Eur J Immunol. 2008 Sep;38(9):2389-400. doi: 10.1002/eji.200838470.
3
Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development.转录因子E2-2是浆细胞样树突状细胞发育的关键特异性调节因子。
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The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development.转录因子Spi-B在浆细胞样树突状细胞前体中表达，并抑制T细胞、B细胞和自然杀伤细胞的发育。
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The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1.转录因子 Spi-B 通过直接诱导抗凋亡基因 BCL2-A1 调节人浆细胞样树突状细胞的存活。
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Transcriptional dynamics and epigenetic regulation of E and ID protein encoding genes during human T cell development.人类 T 细胞发育过程中 E 和 ID 蛋白编码基因的转录动态和表观遗传调控。
Front Immunol. 2022 Jul 28;13:960918. doi: 10.3389/fimmu.2022.960918. eCollection 2022.
2
HEB in the spotlight: Transcriptional regulation of T-cell specification, commitment, and developmental plasticity.成为焦点的HEB：T细胞特化、定向分化及发育可塑性的转录调控
Clin Dev Immunol. 2012;2012:678705. doi: 10.1155/2012/678705. Epub 2012 Apr 22.
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Plasmacytoid dendritic cells in antiviral immunity and autoimmunity.浆细胞样树突状细胞在抗病毒免疫和自身免疫中的作用。
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本文引用的文献

1
Development of human plasmacytoid dendritic cells depends on the combined action of the basic helix-loop-helix factor E2-2 and the Ets factor Spi-B.人类浆细胞样树突状细胞的发育依赖于碱性螺旋-环-螺旋因子E2-2和Ets因子Spi-B的联合作用。
Eur J Immunol. 2008 Sep;38(9):2389-400. doi: 10.1002/eji.200838470.
2
The STATs on dendritic cell development.树突状细胞发育中的信号转导和转录激活因子
Immunity. 2008 Apr;28(4):490-2. doi: 10.1016/j.immuni.2008.03.006.
3
The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8.信号转导子STAT5通过抑制转录因子IRF8来抑制浆细胞样树突状细胞的发育。
Immunity. 2008 Apr;28(4):509-20. doi: 10.1016/j.immuni.2008.02.013. Epub 2008 Mar 13.
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Development of dendritic-cell lineages.树突状细胞谱系的发育。
Immunity. 2007 Jun;26(6):741-50. doi: 10.1016/j.immuni.2007.06.006.
5
Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development.Flt3信号转导级联的激活可挽救并增强I型干扰素产生及树突状细胞的发育。
J Exp Med. 2006 Jan 23;203(1):227-38. doi: 10.1084/jem.20051645. Epub 2006 Jan 17.
6
Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment.缺乏红系-巨核系分化潜能的Flt3+淋巴-髓系干细胞的鉴定：成人血细胞谱系定向分化的修订路线图
Cell. 2005 Apr 22;121(2):295-306. doi: 10.1016/j.cell.2005.02.013.
7
IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors.IPC：专业的1型干扰素产生细胞和浆细胞样树突状细胞前体。
Annu Rev Immunol. 2005;23:275-306. doi: 10.1146/annurev.immunol.23.021704.115633.
8
IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity.干扰素调节因子-4和-8调控树突状细胞亚群的发育及其功能多样性。
J Immunol. 2005 Mar 1;174(5):2573-81. doi: 10.4049/jimmunol.174.5.2573.
9
The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development.ETS转录因子Spi-B是人类浆细胞样树突状细胞发育所必需的。
J Exp Med. 2004 Dec 6;200(11):1503-9. doi: 10.1084/jem.20041231.
10
E47, IRF-4, and PU.1 synergize to induce B-cell-specific activation of the class II transactivator promoter III (CIITA-PIII).E47、IRF-4和PU.1协同作用，诱导II类反式激活因子启动子III（CIITA-PIII）的B细胞特异性激活。
Blood. 2004 Nov 1;104(9):2849-57. doi: 10.1182/blood-2004-03-0790. Epub 2004 Jul 8.

E盒蛋白E2-2是浆细胞样树突状细胞发育的关键调节因子。

E-box protein E2-2 is a crucial regulator of plasmacytoid DC development.

作者信息

Esashi Eiji, Liu Yong-Jun

机构信息

Department of Immunology and Center for Cancer Immunology Research, University of Texas, M. D. Anderson Cancer Center, Houston, TX 77030, USA.

出版信息

Eur J Immunol. 2008 Sep;38(9):2386-8. doi: 10.1002/eji.200838763.

DOI:10.1002/eji.200838763
PMID:18792016
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3652573/
Abstract

DC play central roles in priming both innate and adaptive immune responses. Multiple DC subsets have been identified on the basis of their phenotype and function. Plasmacytoid DC (pDC) are professional IFN-producing cells that play an essential role in anti-viral immunity. A series of recent studies demonstrates that the regulation of pDC development is different from other types of DC. In this issue of the European Journal of Immunology, new insight is provided into how human pDC development is regulated by various transcription factors, in particular by the Ets family protein Spi-B and E-box protein E2-2.

摘要

树突状细胞（DC）在启动先天性和适应性免疫反应中发挥核心作用。基于其表型和功能已鉴定出多个DC亚群。浆细胞样DC（pDC）是产生干扰素的专职细胞，在抗病毒免疫中起重要作用。最近的一系列研究表明，pDC发育的调控不同于其他类型的DC。在本期《欧洲免疫学杂志》中，我们对人类pDC发育如何受到各种转录因子，特别是Ets家族蛋白Spi-B和E-box蛋白E2-2的调控有了新的认识。