浆细胞样树突状细胞发育的调控。
Regulation of plasmacytoid dendritic cell development.
机构信息
Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.
出版信息
Curr Opin Immunol. 2010 Apr;22(2):206-11. doi: 10.1016/j.coi.2010.01.005. Epub 2010 Feb 9.
Abstract
Plasmacytoid dendritic cells (PDC) represent a distinct immune cell type specialized in direct virus recognition and rapid secretion of type I interferon. The origin and lineage affiliation of PDC have been controversial, partly because PDC show features of both lymphocytes and dendritic cells (DC). Recent studies helped elucidate the cellular and molecular basis of PDC development. In particular, the common developmental origin and genetic similarity of PDC and classical antigen-presenting DC have been established. In addition, E protein transcription factor E2-2 was shown to control lineage commitment and gene expression program of PDC. Because E proteins are essential regulators of lymphocyte development, E2-2 activity may underlie the distinct 'lymphoid' features of PDC.
摘要
浆细胞样树突状细胞 (PDC) 是一种独特的免疫细胞类型，专门从事直接病毒识别和 I 型干扰素的快速分泌。PDC 的起源和谱系归属一直存在争议，部分原因是 PDC 表现出淋巴细胞和树突状细胞 (DC) 的特征。最近的研究有助于阐明 PDC 发育的细胞和分子基础。特别是，已经确立了 PDC 和经典抗原呈递 DC 的共同发育起源和遗传相似性。此外，E 蛋白转录因子 E2-2 被证明控制 PDC 的谱系决定和基因表达程序。由于 E 蛋白是淋巴细胞发育的必需调节剂，因此 E2-2 的活性可能是 PDC 独特的“淋巴样”特征的基础。
相似文献
1
Regulation of plasmacytoid dendritic cell development.浆细胞样树突状细胞发育的调控。
Curr Opin Immunol. 2010 Apr;22(2):206-11. doi: 10.1016/j.coi.2010.01.005. Epub 2010 Feb 9.
2
Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development.转录因子E2-2是浆细胞样树突状细胞发育的关键特异性调节因子。
Cell. 2008 Oct 3;135(1):37-48. doi: 10.1016/j.cell.2008.09.016.
3
Plasmacytoid dendritic cell development.浆细胞样树突状细胞的发育。
Adv Immunol. 2013;120:105-26. doi: 10.1016/B978-0-12-417028-5.00004-1.
4
Development of human plasmacytoid dendritic cells depends on the combined action of the basic helix-loop-helix factor E2-2 and the Ets factor Spi-B.人类浆细胞样树突状细胞的发育依赖于碱性螺旋-环-螺旋因子E2-2和Ets因子Spi-B的联合作用。
Eur J Immunol. 2008 Sep;38(9):2389-400. doi: 10.1002/eji.200838470.
5
Dendritic cells: transcriptional control of plasmacytoid dendritic cell development by E2-2.
Immunol Cell Biol. 2009 Jan;87(1):1-2. doi: 10.1038/icb.2008.93. Epub 2008 Dec 2.
6
E-box protein E2-2 is a crucial regulator of plasmacytoid DC development.E盒蛋白E2-2是浆细胞样树突状细胞发育的关键调节因子。
Eur J Immunol. 2008 Sep;38(9):2386-8. doi: 10.1002/eji.200838763.
7
Continuous expression of the transcription factor e2-2 maintains the cell fate of mature plasmacytoid dendritic cells.转录因子 e2-2 的持续表达维持了成熟浆细胞样树突状细胞的细胞命运。
Immunity. 2010 Dec 14;33(6):905-16. doi: 10.1016/j.immuni.2010.11.023. Epub 2010 Dec 9.
8
CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells.CX3CR1+CD8α+树突状细胞是与浆细胞样树突状细胞相关的稳定群体。
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14745-50. doi: 10.1073/pnas.1001562107. Epub 2010 Aug 2.
9
CD123bright plasmacytoid predendritic cells: progenitors undergoing cell fate conversion?CD123高表达浆细胞样前树突状细胞：正在经历细胞命运转变的祖细胞？
J Immunol. 2002 Jul 1;169(1):75-83. doi: 10.4049/jimmunol.169.1.75.
10
Isoform-Specific Expression and Feedback Regulation of E Protein TCF4 Control Dendritic Cell Lineage Specification.E蛋白TCF4的异构体特异性表达及反馈调节控制树突状细胞谱系定向分化
Immunity. 2017 Jan 17;46(1):65-77. doi: 10.1016/j.immuni.2016.11.006. Epub 2016 Dec 13.
引用本文的文献
1
Single-cell transcriptome analysis of bronchoalveolar lavage during early SARS-CoV-2 infection.新型冠状病毒2型（SARS-CoV-2）早期感染期间支气管肺泡灌洗的单细胞转录组分析
Microbiol Spectr. 2025 Sep 2;13(9):e0271524. doi: 10.1128/spectrum.02715-24. Epub 2025 Jul 31.
2
Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling.TCF4的抑制促进了一个由ZC3H12A介导的、涉及IL-17RA/IL-17RE表皮信号的自我维持性炎症反馈循环。
JCI Insight. 2024 Mar 12;9(8):e172764. doi: 10.1172/jci.insight.172764.
3
The Immunomodulatory Role of Hypoxic Tumor-Derived Extracellular Vesicles.缺氧肿瘤衍生细胞外囊泡的免疫调节作用
Cancers (Basel). 2022 Aug 18;14(16):4001. doi: 10.3390/cancers14164001.
4
A Case of Axial Spondyloarthritis Triggered by SARS-CoV-2 Infection.一例由SARS-CoV-2感染引发的轴性脊柱关节炎病例。
Cureus. 2022 Mar 5;14(3):e22860. doi: 10.7759/cureus.22860. eCollection 2022 Mar.
5
Modulation of the immune response by heterogeneous monocytes and dendritic cells in lung cancer.肺癌中异质性单核细胞和树突状细胞对免疫反应的调节
World J Clin Oncol. 2021 Nov 24;12(11):966-982. doi: 10.5306/wjco.v12.i11.966.
6
Blastic Plasmacytoid Dendritic Cell Neoplasm: Progress in Cell Origin, Molecular Biology, Diagnostic Criteria and Therapeutic Approaches.原始滤泡性淋巴瘤：细胞起源、分子生物学、诊断标准和治疗方法的进展。
Curr Med Sci. 2021 Jun;41(3):405-419. doi: 10.1007/s11596-021-2393-3. Epub 2021 Jul 3.
7
SARS-CoV-2 Infection Induces Psoriatic Arthritis Flares and Enthesis Resident Plasmacytoid Dendritic Cell Type-1 Interferon Inhibition by JAK Antagonism Offer Novel Spondyloarthritis Pathogenesis Insights.严重急性呼吸综合征冠状病毒2感染引发银屑病关节炎发作，且通过JAK拮抗作用对驻跗骨浆细胞样树突状细胞1型干扰素的抑制为脊柱关节炎发病机制提供了新见解。
Front Immunol. 2021 Apr 15;12:635018. doi: 10.3389/fimmu.2021.635018. eCollection 2021.
8
Detection of selection signatures for response to Aleutian mink disease virus infection in American mink.检测针对阿勒坦病毒感染的美国水貂的反应的选择特征。
Sci Rep. 2021 Feb 3;11(1):2944. doi: 10.1038/s41598-021-82522-8.
9
Myeloid and Plasmacytoid Dendritic Cells and Cancer - New Insights.髓样和浆细胞样树突状细胞与癌症——新见解
Open Access Maced J Med Sci. 2019 Oct 13;7(19):3324-3340. doi: 10.3889/oamjms.2019.735. eCollection 2019 Oct 15.
10
Understanding the Functional Properties of Neonatal Dendritic Cells: A Doorway to Enhance Vaccine Effectiveness?了解新生儿树突状细胞的功能特性：增强疫苗效力的新途径？
Front Immunol. 2019 Jan 10;9:3123. doi: 10.3389/fimmu.2018.03123. eCollection 2018.
本文引用的文献
1
Asynchronous RAG-1 expression during B lymphopoiesis.B 淋巴细胞发生过程中的 RAG-1 异步表达。
J Immunol. 2009 Dec 15;183(12):7768-77. doi: 10.4049/jimmunol.0902333.
2
Cutting edge: B220+CCR9- dendritic cells are not plasmacytoid dendritic cells but are precursors of conventional dendritic cells.前沿：B220+CCR9-树突状细胞不是浆细胞样树突状细胞，而是传统树突状细胞的前体。
J Immunol. 2009 Aug 1;183(3):1514-7. doi: 10.4049/jimmunol.0901524. Epub 2009 Jul 1.
3
Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction.通过BST2与ILT7受体相互作用对浆细胞样树突状细胞中TLR7/9反应的调节。
J Exp Med. 2009 Jul 6;206(7):1603-14. doi: 10.1084/jem.20090547. Epub 2009 Jun 29.
4
CD2 distinguishes two subsets of human plasmacytoid dendritic cells with distinct phenotype and functions.CD2可区分出具有不同表型和功能的两类人浆细胞样树突状细胞。
J Immunol. 2009 Jun 1;182(11):6815-23. doi: 10.4049/jimmunol.0802008.
5
In vivo analysis of dendritic cell development and homeostasis.树突状细胞发育与稳态的体内分析。
Science. 2009 Apr 17;324(5925):392-7. doi: 10.1126/science.1170540. Epub 2009 Mar 12.
6
CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation.CX3CR1+ CD115+ CD135+ 常见巨噬细胞/树突状细胞前体以及CX3CR1在其对炎症反应中的作用
J Exp Med. 2009 Mar 16;206(3):595-606. doi: 10.1084/jem.20081385. Epub 2009 Mar 9.
7
E and ID proteins branch out.E蛋白和ID蛋白呈分支状分布。
Nat Rev Immunol. 2009 Mar;9(3):175-84. doi: 10.1038/nri2507.
8
Dendritic cell homeostasis.树突状细胞稳态
Blood. 2009 Apr 9;113(15):3418-27. doi: 10.1182/blood-2008-12-180646. Epub 2009 Jan 27.
9
Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC.通过Ly49Q对I类主要组织相容性复合体的识别实现浆细胞样树突状细胞功能的正向调节。
J Exp Med. 2008 Dec 22;205(13):3187-99. doi: 10.1084/jem.20080718. Epub 2008 Dec 15.
10
Developmental regulation of MHC II expression and transport in human plasmacytoid-derived dendritic cells.人浆细胞样树突状细胞中MHC II表达与转运的发育调控
Blood. 2009 Mar 5;113(10):2127-35. doi: 10.1182/blood-2008-10-178152. Epub 2008 Nov 17.
Zotero 插件