Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.
Curr Opin Immunol. 2010 Apr;22(2):206-11. doi: 10.1016/j.coi.2010.01.005. Epub 2010 Feb 9.
Plasmacytoid dendritic cells (PDC) represent a distinct immune cell type specialized in direct virus recognition and rapid secretion of type I interferon. The origin and lineage affiliation of PDC have been controversial, partly because PDC show features of both lymphocytes and dendritic cells (DC). Recent studies helped elucidate the cellular and molecular basis of PDC development. In particular, the common developmental origin and genetic similarity of PDC and classical antigen-presenting DC have been established. In addition, E protein transcription factor E2-2 was shown to control lineage commitment and gene expression program of PDC. Because E proteins are essential regulators of lymphocyte development, E2-2 activity may underlie the distinct 'lymphoid' features of PDC.
浆细胞样树突状细胞 (PDC) 是一种独特的免疫细胞类型，专门从事直接病毒识别和 I 型干扰素的快速分泌。PDC 的起源和谱系归属一直存在争议，部分原因是 PDC 表现出淋巴细胞和树突状细胞 (DC) 的特征。最近的研究有助于阐明 PDC 发育的细胞和分子基础。特别是，已经确立了 PDC 和经典抗原呈递 DC 的共同发育起源和遗传相似性。此外，E 蛋白转录因子 E2-2 被证明控制 PDC 的谱系决定和基因表达程序。由于 E 蛋白是淋巴细胞发育的必需调节剂，因此 E2-2 的活性可能是 PDC 独特的“淋巴样”特征的基础。
