Arenas M D, Gil M T, Gutiérrez M D, Malek T, Moledous A, Salinas A, Alvarez-Ude F
Servicio de Nefrologia, Hospital Perpetuo Socorro, Alicante, Spain.
Clin Nephrol. 2008 Sep;70(3):261-4. doi: 10.5414/cnp70261.
Calcific uremic arteriolopathy (CUA) is a rare but serious complication of end-stage renal disease presenting as painful cutaneous lesions and progressing to non-healing ulcers and gangrene. This syndrome is associated with calcium and phosphorus deposits within small arteries of the skin. The pathognomonic lesion is vascular calcification with intimal arterial hypertrophy and superimposed small-vessel thrombosis. The condition is being increasingly recognized and reported as a contributing factor to death in dialysis patients, with secondary infection and sepsis as the major cause of mortality. No standard treatment has been established for this syndrome. We present the therapeutic approach employed in two patients, which successfully resulted in healing of the lesions, using a combination of measures to control the factors potentially related to development of CUA and hyperbaric oxygen therapy.
钙化性尿毒症性小动脉病（CUA）是终末期肾病的一种罕见但严重的并发症，表现为疼痛性皮肤病变，并进展为不愈合的溃疡和坏疽。该综合征与皮肤小动脉内的钙和磷沉积有关。其特征性病变是血管钙化伴内膜动脉肥厚和叠加的小血管血栓形成。这种疾病越来越被认为是透析患者死亡的一个促成因素，继发感染和脓毒症是主要死亡原因。目前尚未确立针对该综合征的标准治疗方法。我们介绍了两名患者所采用的治疗方法，通过综合采取措施控制可能与CUA发生相关的因素并结合高压氧治疗，成功使病变愈合。
