Guhl Guillermo, García-Díez Amaro
Department of Dermatology, Hospital Universitario de la Princesa, Madrid, Spain.
Dermatol Clin. 2008 Oct;26(4):541-51, viii-ix. doi: 10.1016/j.det.2008.06.003.
Neutrophilic panniculitis encompasses a heterogeneous group of diseases histopathologically characterized by an inflammatory infiltrate in the subcutaneous fat mainly composed of mature neutrophils. This group of panniculitides includes alpha(1)-antitrypsin deficiency, infectious panniculitis, factitious panniculitis, subcutaneous Sweet syndrome, neutrophilic/pustular panniculitis associated with rheumatoid arthritis, erythema nodosum-like lesions of Behçet disease, bowel bypass panniculitis, and iatrogenic panniculitis. This article reviews subcutaneous Sweet syndrome, which is a rare idiopathic panniculitis characterized by a dense neutrophilic infiltrate in the subcutis and is often related to hematologic malignancies. The relationship of subcutaneous Sweet syndrome and erythema nodosum is discussed as well as the differential diagnosis with other neutrophilic panniculitis.
中性粒细胞性脂膜炎是一组异质性疾病，其组织病理学特征为皮下脂肪组织出现主要由成熟中性粒细胞组成的炎性浸润。这组脂膜炎包括α1抗胰蛋白酶缺乏症、感染性脂膜炎、人为性脂膜炎、皮下Sweet综合征、与类风湿关节炎相关的中性粒细胞性/脓疱性脂膜炎、白塞病的结节红斑样皮损、肠道旁路性脂膜炎和医源性脂膜炎。本文综述皮下Sweet综合征，它是一种罕见的特发性脂膜炎，其特征为皮下组织有密集的中性粒细胞浸润，且常与血液系统恶性肿瘤相关。文中还讨论了皮下Sweet综合征与结节红斑的关系以及与其他中性粒细胞性脂膜炎的鉴别诊断。
