Källén R, Borgström A, Fält K
Department of Surgery, Malmäo General Hospital, Sweden.
Eur Surg Res. 1991;23(1):9-19. doi: 10.1159/000129131.
Urine cytology and blood lymphocyte blastogenesis were evaluated as indicators of allograft rejection in a porcine pancreatic transplantation model. The percentage of activated lymphocytes and/or blasts was significantly increased during the rejection phase. Positive cytology was present in all rejection episodes. An increased thymidine uptake of blood lymphocytes and a decreased uridine/thymidine uptake quotient were seen prior to the onset of rejection. The reported dissociation of anionic and cationic trypsin levels in serum and urine after transplantation was not seen after simple urinary diversion of the pancreatic juice. This supports the hypothesis that a decreased synthesis of cationic trypsinogen compared with anionic trypsinogen occurs after porcine pancreatic transplantation.
在猪胰腺移植模型中，评估尿细胞学和血液淋巴细胞增殖反应作为同种异体移植排斥反应的指标。在排斥反应阶段，活化淋巴细胞和/或母细胞的百分比显著增加。所有排斥反应发作时尿细胞学均呈阳性。在排斥反应发作前，观察到血液淋巴细胞的胸腺嘧啶核苷摄取增加，尿苷/胸腺嘧啶核苷摄取商降低。在胰液单纯尿流改道后，未观察到移植后血清和尿液中阴离子和阳离子胰蛋白酶水平的报道解离情况。这支持了猪胰腺移植后阳离子胰蛋白酶原合成与阴离子胰蛋白酶原相比减少的假说。
