用于肾脏修复的干细胞：治疗急性肾衰竭的有效工具？

Stem cells for kidney repair: useful tool for acute renal failure?

作者信息

Yokoo Takashi, Kawamura Tetsuya, Kobayashi Eiji

机构信息

Project Laboratory for Kidney Regeneration, Division of Nephrology and Hypertension, Department of Internal Medicine, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan.

出版信息

Kidney Int. 2008 Oct;74(7):847-9. doi: 10.1038/ki.2008.327.

DOI:10.1038/ki.2008.327

PMID:18794815

Abstract

Several cell types isolated from adult tissues have been reported to differentiate into mature kidney cells that may participate in renal repair after systemic administration. Chen et al. report that local mesenchymal stem cells derived from adult mouse kidneys are another source of cells with similar properties. Although these cells have the potential to differentiate into endothelial-lineage cell types, their therapeutic benefit to the ischemic kidney is mainly via the production of renoprotective factors.

摘要

据报道，从成年组织中分离出的几种细胞类型可分化为成熟的肾细胞，在全身给药后可能参与肾脏修复。陈等人报告称，源自成年小鼠肾脏的局部间充质干细胞是具有类似特性的细胞的另一个来源。尽管这些细胞有可能分化为内皮谱系细胞类型，但其对缺血性肾脏的治疗益处主要是通过产生肾脏保护因子实现的。