新型维甲酸 9cUAB30 抑制端粒酶并诱导 HL60 细胞凋亡。
The Novel Retinoid, 9cUAB30, Inhibits Telomerase and Induces Apoptosis in HL60 Cells.
机构信息
Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
出版信息
Transl Oncol. 2008 Sep;1(3):148-52. doi: 10.1593/tlo.08142.
Abstract
Telomerase, a ribonucleoprotein important to neoplastic immortality, is up-regulated in approximately 85% of cancers, including leukemias. In this study, 9cUAB30, a novel retinoic acid, resulted in differentiation of HL60 leukemia cells as indicated by morphologic changes characteristic of granulocytes. It also caused a down-regulation of hTERT gene expression and a decrease in telomerase activity. Telomerase inhibition was followed by loss of proliferative capacity, induction of apoptosis, and partial differentiation. These findings demonstrate the effectiveness of 9cUAB30 at inhibiting telomerase activity by down-regulating hTERT gene expression in human leukemic cells.
摘要
端粒酶是一种与肿瘤永生有关的核糖核蛋白，约 85%的癌症包括白血病中都存在上调。在这项研究中，新型维甲酸 9cUAB30 导致 HL60 白血病细胞分化，表现为粒细胞特征的形态学变化。它还导致 hTERT 基因表达下调和端粒酶活性降低。端粒酶抑制后，增殖能力丧失、凋亡诱导和部分分化。这些发现表明 9cUAB30 通过下调人白血病细胞中 hTERT 基因的表达抑制端粒酶活性是有效的。
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