Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Cancer Prev Res (Phila). 2023 Jan 4;16(1):47-55. doi: 10.1158/1940-6207.CAPR-22-0210.
Bexarotene is a rexinoid that has been shown to prevent mammary tumors in mouse models but oral dosing has toxicities. This phase I study evaluates topical bexarotene, as a potential chemoprevention agent, for safety and toxicity in high-risk women for breast cancer.
倍他罗汀是一种维甲酸类药物,已被证明可预防小鼠模型中的乳腺肿瘤,但口服给药有毒性。这项 I 期研究评估了局部应用倍他罗汀作为一种潜在的化学预防剂,用于治疗乳腺癌高危女性的安全性和毒性。