Makishima M, Honma Y, Hozumi M, Sampi K, Hattori M, Motoyoshi K
Saitama Cancer Center, Japan.
FEBS Lett. 1991 Aug 5;287(1-2):175-7. doi: 10.1016/0014-5793(91)80044-4.
Inhibitors of myosin light chain kinase, 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-9) and 1-(5-iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-7), induced Nitroblue tetrazolium reducing activity, lysozyme activity and morphological maturation of human monoblastic U937, THP-1 and promyelocytic HL-60 cells, but not of erythroblastic K562 cells. However, three analogs of ML-9, which are an inhibitor and an activator of protein kinase C, and a calmodulin antagonist, respectively, did not induce differentiation of the cells.
肌球蛋白轻链激酶抑制剂1-(5-氯萘-1-磺酰基)-1H-六氢-1,4-二氮杂卓盐酸盐（ML-9）和1-(5-碘萘-1-磺酰基)-1H-六氢-1,4-二氮杂卓盐酸盐（ML-7）可诱导人单核细胞U937、THP-1以及早幼粒细胞HL-60细胞的硝基蓝四氮唑还原活性、溶菌酶活性和形态成熟，但对成红细胞K562细胞无此作用。然而，ML-9的三种类似物，分别为蛋白激酶C的抑制剂、激活剂和钙调蛋白拮抗剂，均未诱导细胞分化。
