Pellegrino Antonio, Signorelli Mauro, Fruscio Robert, Villa Annalisa, Buda Alessandro, Beretta Pietro, Garbi Annalisa, Vitobello Domenico
Division of Gynecologic Oncology, Clinica Ostetrica e Ginecologica, Ospedale San Gerardo, University of Milan-Bicocca, Monza, Milan, Italy.
Arch Gynecol Obstet. 2009 May;279(5):655-60. doi: 10.1007/s00404-008-0790-5. Epub 2008 Sep 16.
The aim of this study was to describe the feasibility and morbidity rates associated with total laparoscopic radical hysterectomy (TLRH) with or without pelvic lymphadenectomy for stage I endometrial cancer in obese women.
Obese patients with stage I endometrial cancer who underwent total laparoscopic radical surgery at the Department of Obstetrics and Gynecology of San Gerardo Hospital were compared to nonobese patients. The same group of obese patients was compared with patients who underwent radical laparotomic surgery. Obesity was defined as a body mass index more than 30 kg/m(2).
Between September 2003 and September 2007, 75 women underwent TLRH. Median age was 54 years and median body mass index was 28 kg/m(2). Thirty-seven women were obese. There were no differences between nonobese and obese women in operative, time length of parametria and pelvic nodes removed and operative or late complications. Blood loss was significantly higher in obese patients. Comparing retrospectively laparoscopy and laparotomy in obese women treated in our center, laparotomy was associated with decreased operative time, but also with increased blood loss, transfusion rate, duration of hospitalization and frequency of post surgical complications.
Total laparoscopic radical hysterectomy (with pelvic lymphadenectomy) is a safe option in patients with endometrial cancer. Obesity is not a contraindication to perform a TRLH with no differences in surgical parameters between obese and nonobese population. TLRH show a significant decrease of complications compared to laparotomic radical surgery in obese women.
本研究旨在描述肥胖女性I期子宫内膜癌行全腹腔镜根治性子宫切除术(TLRH)(无论是否行盆腔淋巴结清扫术)的可行性及发病率。
将在圣杰拉尔多医院妇产科接受全腹腔镜根治性手术的肥胖I期子宫内膜癌患者与非肥胖患者进行比较。将同一组肥胖患者与接受开腹根治性手术的患者进行比较。肥胖定义为体重指数超过30kg/m²。
2003年9月至2007年9月期间,75名女性接受了TLRH。中位年龄为54岁,中位体重指数为28kg/m²。37名女性肥胖。非肥胖和肥胖女性在手术、宫旁组织和切除盆腔淋巴结的时间长度以及手术或晚期并发症方面无差异。肥胖患者的失血量明显更高。回顾性比较本中心治疗的肥胖女性的腹腔镜手术和开腹手术,开腹手术的手术时间缩短,但失血量增加、输血率升高、住院时间延长且术后并发症发生率增加。
全腹腔镜根治性子宫切除术(加盆腔淋巴结清扫术)对子宫内膜癌患者是一种安全的选择。肥胖并非行TLRH的禁忌证,肥胖和非肥胖人群在手术参数上无差异。与肥胖女性的开腹根治性手术相比,TLRH的并发症显著减少。