Nordenvall M, Ullberg U, Laurin J, Lingman G, Sandstedt B, Ulmsten U
Department of Obstetrics & Gynecology, Karolinska Institute, Danderyd Hospital, Sweden.
Eur J Obstet Gynecol Reprod Biol. 1991 Jul 25;40(3):179-90. doi: 10.1016/0028-2243(91)90115-2.
The association between umbilical artery flow velocity waveforms, placental morphology and arterial vascular pattern was investigated in 30 pregnant women at risk for intra-uterine growth retardation. The blood velocity waveform was assessed in the umbilical arteries with pulsed Doppler ultrasound. Placentas from fetuses with an end-diastolic zero flow were small and thick with an extrachorial configuration, marginal cord insertion, magistral or mixed allantochorial vessel pattern and few cotyledons. The incidence and the extension of gross lesions were slightly increased in these placentas compared to placentas from fetuses with a normal S/D ratio (peak systolic velocity/minimum diastolic velocity). Placentas from fetuses with an increased S/D ratio (greater than +2SD) were large and thin with a high maximum diameter/maximum thickness ratio. Heavily smoking mothers were overrepresented in the group, with an increased S/D ratio and corresponding SGA infants. End-diastolic zero flow in the umbilical artery was strongly correlated with placental developmental abnormalities.
对30名有宫内生长迟缓风险的孕妇，研究了脐动脉血流速度波形、胎盘形态与动脉血管模式之间的关联。用脉冲多普勒超声评估脐动脉中的血流速度波形。舒张末期血流为零的胎儿的胎盘小而厚，具有绒毛膜外结构、边缘性脐带插入、主型或混合型尿囊血管模式以及小叶较少。与舒张末期血流正常的胎儿的胎盘相比，这些胎盘 gross lesions 的发生率和范围略有增加。舒张末期血流速度比值升高（大于+2SD）的胎儿的胎盘大而薄，最大直径/最大厚度比值高。该组中重度吸烟母亲的比例过高，其舒张末期血流速度比值升高，相应地出现小于胎龄儿。脐动脉舒张末期血流为零与胎盘发育异常密切相关。 （注：原文中“gross lesions”未明确其医学含义，直接保留英文表述）
