Hitschold T, Weiss E, Beck T, Hünterfering H, Berle P
Department of Obstetrics and Gynecology, HSK-Klinikum, Wiesbaden, Germany.
Am J Obstet Gynecol. 1993 Apr;168(4):1260-4. doi: 10.1016/0002-9378(93)90377-u.
The placental vascular architecture of small-for-gestational-age fetuses seems to have an impact on the flow patterns in the umbilical arteries.
Blood flow velocity waveforms of the umbilical arteries were measured by Doppler ultrasonography in nine small-for-gestational-age fetuses with elevated systolic/diastolic ratios of the umbilical arteries, seven small-for-gestational-age fetuses with normal flow patterns, and 14 appropriate-for-gestational-age fetuses with normal flow patterns. After delivery histomorphometric placental investigations were performed.
Reduced end-diastolic flow velocities were significantly associated with both a reduction of vascularization within the terminal villi and adverse diffusion conditions, indicating insufficient functional maturity. The perfusion and diffusion capacity of small-for-gestational-age placentas with normal umbilical artery flow velocity waveforms was similar or even slightly better compared with the appropriate-for-gestational-age control values.
These data suggest that Doppler flow velocimetry in the umbilical arteries is predictive of a vascular lesion within the placentas of small-for-gestational-age fetuses.
小于胎龄儿的胎盘血管结构似乎对脐动脉血流模式有影响。
采用多普勒超声测量9例脐动脉收缩/舒张比升高的小于胎龄儿、7例血流模式正常的小于胎龄儿以及14例血流模式正常的适于胎龄儿的脐动脉血流速度波形。分娩后进行胎盘组织形态计量学研究。
舒张末期血流速度降低与终末绒毛内血管化减少及不良扩散条件显著相关，提示功能成熟不足。脐动脉血流速度波形正常的小于胎龄胎盘的灌注和扩散能力与适于胎龄对照值相似，甚至略好。
这些数据表明，脐动脉多普勒血流测速可预测小于胎龄儿胎盘内的血管病变。
