Nissen Judith Becker, Thomsen Per Hove
Børne- og Ungdomspsykiatrisk Regionscenter, Arhus Universitetshospital, DK-8240 Risskov.
Ugeskr Laeger. 2008 Sep 8;170(37):2874-6.
Obsessive-compulsive disorder (OCD) is a frequent disorder and glutamate seems to be an important transmitter. The effect of glutamate depends on the level as well as the effect mediated through glutamate receptors. The level is altered in brain areas that are involved in OCD. Genes encoding receptors, enzymes involved in the metabolism and transport proteins are located in regions that are related to OCD. Pharmacogenetic studies examining the genetic variations in the glutaminate system are lacking. The aim was to examine the current knowledge on the glutaminate system in the development and maintenance of OCD.
强迫症（OCD）是一种常见疾病，谷氨酸似乎是一种重要的神经递质。谷氨酸的作用取决于其水平以及通过谷氨酸受体介导的效应。在参与强迫症的脑区中，谷氨酸水平会发生改变。编码受体、参与代谢的酶以及转运蛋白的基因位于与强迫症相关的区域。目前缺乏研究谷氨酸系统基因变异的药物遗传学研究。本研究旨在探讨谷氨酸系统在强迫症发生发展及维持过程中的现有知识。
