Gonda Xénia, Jekkel Eva, Varga Anna, Miklósi Mónika, Forintos Dóra Perczel
Farmakológiai és Farmakoterápiás Intézet, Semmelweis Egyetem, Orvostudományi Kar.
Neuropsychopharmacol Hung. 2008 Oct;10(4):225-32.
Psychiatric disorders are difficult to explain from an evolutionary aspect, since it is hard to reason how a characteristic carrying a reproductive disadvantage survives through natural selection. There are several evolution-based papers concerning obsessive-compulsive disorder (OCD), which aim at resolving this contradiction. Recent studies provided considerable evidence in support for the evolutionary theories of OCD. Research confirmed an important role for genetic factors in the background of OCD, and neuroanatomic studies supported that neuroanatomical structures playing a role in OCD are those areas which are activated during the processing of danger and threat. From the evolutionary aspect OCD can be explained both from the individual and group selection aspect. According to the theory of individual selection, OCD symptoms are based on such behaviors which are by themselves advantageous serving individual survival and reproduction and therefore carry on through natural selection. According to group selection theory, although OCD is disadvantageous for the individual, it is adaptive for the survival of the group. In our paper we review the individual and group selection theories of OCD, and we also outline the continuity and discontinuity theories which show a significant overlap with the evolutionary theories. We review characteristic age and gender differences related to OCD from this aspect. The evolutionary approach to OCD is important in understanding the background factors, development and symptoms of OCD, which mean new tools in the prevention and treatment of this disorder.
从进化的角度很难解释精神疾病,因为很难推断出一种具有生殖劣势的特征是如何通过自然选择留存下来的。有几篇基于进化的论文探讨了强迫症(OCD),旨在解决这一矛盾。近期研究提供了大量证据支持强迫症的进化理论。研究证实了遗传因素在强迫症背景中的重要作用,神经解剖学研究也支持在强迫症中起作用的神经解剖结构是那些在处理危险和威胁时被激活的区域。从进化的角度来看,强迫症既可以从个体选择方面也可以从群体选择方面来解释。根据个体选择理论,强迫症症状基于本身具有优势的行为,这些行为有利于个体生存和繁殖,因此通过自然选择得以延续。根据群体选择理论,尽管强迫症对个体不利,但对群体生存具有适应性。在我们的论文中,我们回顾了强迫症的个体和群体选择理论,并且还概述了与进化理论有显著重叠的连续性和非连续性理论。我们从这方面回顾了与强迫症相关的特征性年龄和性别差异。强迫症的进化方法对于理解强迫症的背景因素、发展和症状很重要,这意味着在该疾病的预防和治疗方面有了新工具。