离子液体中基于核苷的抗病毒药物的合成。
Synthesis of nucleoside-based antiviral drugs in ionic liquids.
作者信息
Kumar Vineet, Malhotra Sanjay V
机构信息
Laboratory of Synthetic Chemistry, SAIC-Frederick Inc., National Cancer Institute-Frederick, 1050 Boyles Street, Frederick, MD 21702, USA.
出版信息
Bioorg Med Chem Lett. 2008 Oct 15;18(20):5640-2. doi: 10.1016/j.bmcl.2008.08.090. Epub 2008 Aug 29.
PMID:18796352
Abstract
Nucleoside-based antiviral drugs have been synthesized using imidazolium-based ionic liquids as reaction medium. The ionic liquids were proved to be better solvents for all the nucleoside in terms of solubility and reaction medium as compared to conventional molecular solvents.
摘要
基于核苷的抗病毒药物已使用咪唑基离子液体作为反应介质进行合成。与传统分子溶剂相比，离子液体在溶解性和反应介质方面被证明是所有核苷的更好溶剂。
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