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离子液体在制药领域的作用：相关应用概述。

The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications.

机构信息

Department of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal.

出版信息

Int J Mol Sci. 2020 Nov 5;21(21):8298. doi: 10.3390/ijms21218298.

DOI:10.3390/ijms21218298
PMID:33167474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7663996/
Abstract

Solubility, bioavailability, permeation, polymorphism, and stability concerns associated to solid-state pharmaceuticals demand for effective solutions. To overcome some of these drawbacks, ionic liquids (ILs) have been investigated as solvents, reagents, and anti-solvents in the synthesis and crystallization of active pharmaceutical ingredients (APIs), as solvents, co-solvents and emulsifiers in drug formulations, as pharmaceuticals (API-ILs) aiming liquid therapeutics, and in the development and/or improvement of drug-delivery-based systems. The present review focuses on the use of ILs in the pharmaceutical field, covering their multiple applications from pharmaceutical synthesis to drug delivery. The most relevant research conducted up to date is presented and discussed, together with a critical analysis of the most significant IL-based strategies in order to improve the performance of therapeutics and drug delivery systems.

摘要

溶解度、生物利用度、渗透性、多晶型现象和稳定性等问题与固态药物密切相关，这就需要有效的解决方案。为了克服这些缺点，离子液体 (ILs) 已被用作活性药物成分 (API) 合成和结晶中的溶剂、试剂和抗溶剂，药物制剂中的溶剂、共溶剂和乳化剂，用于液体治疗的药物 (API-ILs)，以及药物输送为基础的系统的开发和/或改进。本文综述了离子液体在制药领域的应用，涵盖了从药物合成到药物输送的多种应用。目前呈现并讨论了最相关的研究，并对基于 IL 的最显著策略进行了批判性分析，以提高治疗和药物输送系统的性能。

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