Neal C E, Swan T L, Baker M R, Ellis R L, Katterhagen J G
Department of Radiology, Memorial Medical Center, Springfield, IL 62781.
Gastrointest Radiol. 1991 Summer;16(3):251-5. doi: 10.1007/BF01887359.
Twelve presurgical patients with colorectal carcinoma received a single intravenous infusion of 0.5-20.0 mg of the radiolabeled monoclonal antibody conjugate CYT-103. This product is an immunoconjugate of B72.3 labeled with Indium-111 (111In). Patients underwent preoperative gamma camera imaging and computed tomographic (CT) scanning of the abdomen and pelvis. Fifteen intraabdominal sites of tumor were found at surgery. Monoclonal antibody imaging detected 87% of these lesions, whereas CT of the abdomen and pelvis detected 47%. Monoclonal antibody imaging identified tumor in 27% of the patients in which CT did not identify any sites of tumor. The results of this study indicate that monoclonal antibody imaging using [111In]CYT-103 is useful for the preoperative evaluation of colorectal carcinoma patients and the results are complimentary to CT of the abdomen and the pelvis.
12例结直肠癌患者在手术前接受了一次静脉输注0.5 - 20.0毫克放射性标记的单克隆抗体偶联物CYT - 103。该产品是用铟 - 111（¹¹¹In）标记的B72.3免疫偶联物。患者接受了术前γ相机成像以及腹部和骨盆的计算机断层扫描（CT）。手术中发现了15个腹内肿瘤部位。单克隆抗体成像检测到了其中87%的病变，而腹部和骨盆CT检测到了47%。单克隆抗体成像在CT未发现任何肿瘤部位的27%的患者中识别出了肿瘤。本研究结果表明，使用[¹¹¹In]CYT - 103进行单克隆抗体成像对结直肠癌患者的术前评估有用，且结果与腹部和骨盆CT互补。
