硬皮病患者的反流性食管炎和幽门螺杆菌感染

Reflux esophagitis and Helicobacter pylori infection in patients with scleroderma.

作者信息

Yamaguchi Kanako, Iwakiri Ryuichi, Hara Megumi, Kikkawa Atsushi, Fujise Takehiro, Ootani Hibiki, Shimoda Ryo, Tsunada Seiji, Sakata Hiroyuki, Ushiyama Osamu, Koarada Syuichi, Tada Yoshifumi, Nagasawa Kohei, Fujimoto Kazuma

机构信息

Division of Gastroenterology, Department of Internal Medicine, Saga Medical School, Saga.

出版信息

Intern Med. 2008;47(18):1555-9. doi: 10.2169/internalmedicine.47.1128. Epub 2008 Sep 16.

DOI:10.2169/internalmedicine.47.1128

PMID:18797112

Abstract

OBJECTIVE

This study aimed to evaluate the possible effects of Helicobacter pylori (H. pylori) infection in reflux esophagitis with scleroderma.

PATIENTS AND METHODS

There were a total of 138 patients with scleroderma in our hospital between October 1998 and June 2005. Among these patients, 64 consecutive patients of scleroderma, who did not receive medication for gastrointestinal diseases, underwent endoscopy after informed consent. H. pylori was examined using an H. pylori IgG ELISA. The endoscopists graded esophageal mucosal breaks according to the Los Angeles Classification of Esophagitis.

RESULTS

Among the 64 patients, 37 patients (57.8%) were positive for H. pylori infection. Reflux esophagitis was observed in 10 of 37 H. pylori-positive patients and in 19 of 27 H. pylori-negative patients. Significantly fewer H. pylori-infected patients had reflux esophagitis than H. pylori-negative patients (p<0.01). The odds ratio for H. pylori infection and reflux esophagitis was 0.16 (95%CI; 0.052-0.47).

CONCLUSION

These findings suggest an important role for H. pylori infection in reflux esophagitis with scleroderma.

摘要

目的

本研究旨在评估幽门螺杆菌（H. pylori）感染在硬皮病相关性反流性食管炎中可能产生的影响。

患者与方法

1998年10月至2005年6月期间，我院共有138例硬皮病患者。其中，64例连续入选的未接受过胃肠道疾病治疗的硬皮病患者在签署知情同意书后接受了内镜检查。采用幽门螺杆菌IgG ELISA法检测幽门螺杆菌。内镜医师根据洛杉矶食管炎分类法对食管黏膜破损情况进行分级。

结果

64例患者中，37例（57.8%）幽门螺杆菌感染呈阳性。37例幽门螺杆菌阳性患者中有10例观察到反流性食管炎，27例幽门螺杆菌阴性患者中有19例观察到反流性食管炎。幽门螺杆菌感染患者发生反流性食管炎的比例显著低于幽门螺杆菌阴性患者（p<0.01）。幽门螺杆菌感染与反流性食管炎的比值比为0.16（95%CI；0.052 - 0.47）。