Takata Shinjiro, Takao Shoichiro, Yoshida Shusaku, Hayashi Fumio, Yasui Natsuo
Department of Orthopedics, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.
J Med Invest. 2008 Aug;55(3-4):297-302. doi: 10.2152/jmi.55.297.
We studied the therapeutic effects of one-year alendronate treatment in three cases (two males and one female) of osteoporosis with parietal thinning of skull. Plain radiography and three dimensional computed tomography revealed asymmetric external thinning of the posteromedial part of the bilateral parietal bones. Technetium-99m methylenediphosphate bone scintigraphy did not show any changes in these three cases. Pretreatment levels of urinary type I collagen cross-linked N-telopeptides (NTX) in all three cases were high compared to the normal range. Pretreatment levels of serum bone-specific alkaline phosphatase (BAP) in the two male patients were high in contrast to the normal values in the female patient. Pretreatment mean bone mineral density (BMD) values of the 2nd to 4th lumbar vertebrae (L2-4BMD), head BMD, femoral neck BMD, and whole body BMD of all three patients were low compared with the respective normal ranges. One-year alendronate treatment decreased both urinary NTX and serum BAP in all three cases to normal values. Treatment also increased the whole body BMD in all three cases, the L2-4BMD of the female patient, the femoral neck BMD of the female patient and one male patient, and the head BMD of the female patient when compared to pretreatment levels.
我们研究了阿仑膦酸钠对3例（2例男性和1例女性）伴有颅骨顶骨变薄的骨质疏松症患者进行为期一年治疗的效果。X线平片和三维计算机断层扫描显示双侧顶骨后内侧部分不对称性外部变薄。锝-99m亚甲基二膦酸盐骨闪烁显像在这3例患者中未显示任何变化。与正常范围相比，所有3例患者治疗前尿I型胶原交联N-末端肽（NTX）水平均较高。与女性患者的正常值相比，两名男性患者治疗前血清骨特异性碱性磷酸酶（BAP）水平较高。与各自的正常范围相比，所有3例患者的第2至4腰椎骨密度（L2-4BMD）、头部骨密度、股骨颈骨密度和全身骨密度治疗前平均值均较低。一年的阿仑膦酸钠治疗使所有3例患者的尿NTX和血清BAP均降至正常值。与治疗前水平相比，治疗还提高了所有3例患者的全身骨密度、女性患者的L2-4BMD、女性患者和一名男性患者的股骨颈骨密度以及女性患者的头部骨密度。
