Mateos María Elena, De-la-Cruz Javier, López-Laso Eduardo, Valdés María Dolores, Nogales Angel
Department of Pediatrics, University Hospital Reina Sofía, Córdoba, Spain.
J Pediatr Hematol Oncol. 2008 Jul;30(7):539-42. doi: 10.1097/MPH.0b013e31817580ca.
Identification of iron deficiency (ID) is essential to initiate early treatment to prevent long-term systemic complications of ID anemia. This study was undertaken to evaluate the efficiency of the parameter reticulocyte hemoglobin content (CHr) compared with other laboratory parameters in the assessment of ID in a pediatric population. Blood samples were obtained for 237 children who received routine pediatric care visits in a primary care clinic (mean age: 63.7 mo; male:female ratio: 1.08:1). A multiple stepwise logistic regression analysis identified CHr as the most accurate marker independently associated to ID. A CHr cutoff value of 25 pg (sensitivity: 94%; specificity: 80%) proved an optimal performance predicting ID. Therefore, we conclude that the hematologic parameter CHr constitutes a valuable screening tool for the identification of ID with or without anemia in childhood.
识别缺铁（ID）对于启动早期治疗以预防ID贫血的长期全身并发症至关重要。本研究旨在评估网织红细胞血红蛋白含量（CHr）参数与其他实验室参数相比，在评估儿科人群ID方面的效率。采集了在初级保健诊所接受常规儿科护理就诊的237名儿童的血样（平均年龄：63.7个月；男女比例：1.08:1）。多步逻辑回归分析确定CHr是与ID独立相关的最准确标志物。CHr临界值为25 pg（敏感性：94%；特异性：80%）在预测ID方面表现最佳。因此，我们得出结论，血液学参数CHr是识别儿童有无贫血的ID的有价值的筛查工具。
