Vichnin Michelle
Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Curr Opin Obstet Gynecol. 2008 Oct;20(5):475-8. doi: 10.1097/GCO.0b013e32830d0ce1.
Ectopic pregnancy continues to be an important cause of morbidity and mortality in women. Tubal damage is the likely cause of ectopic pregnancy. Healthcare providers who care for adolescents must screen for and treat sexually transmitted diseases like Chlamydia in order to decrease the risk of tubal damage and ectopic pregnancy. Smoking is a risk factor for ectopic pregnancy and teens should be encouraged to never start smoking or to quit if they already do smoke. Though ectopic pregnancy is more likely to occur in adults, teens are at risk as well, and early diagnosis allows for the possibility of conservative management.
Any teen who presents with amenorrhea, pain, or vaginal bleeding should be evaluated for a possible ectopic pregnancy. Adolescents are more likely to present with pain than adults. Transvaginal ultrasound should be performed and if an intrauterine pregnancy or ectopic pregnancy is not clearly seen, correlation with serum beta-human chorionic gonadotropin levels is done. If the beta-human chorionic gonadotropin level is above the 'discriminatory zone' of 1500 mIU and the transvaginal ultrasound does not show an intrauterine pregnancy, ectopic pregnancy should be suspected.
Unruptured ectopic pregnancy may be treated with expectant management, surgical management, or medical management (methotrexate). Healthy teens with unruptured ectopic pregnancies and who are able and willing to undergo close surveillance may be treated with methotrexate. There are case reports of successful treatment of ectopic pregnancy with methotrexate in adolescents.
异位妊娠仍然是女性发病和死亡的重要原因。输卵管损伤可能是异位妊娠的病因。照顾青少年的医疗服务提供者必须筛查并治疗衣原体等性传播疾病,以降低输卵管损伤和异位妊娠的风险。吸烟是异位妊娠的一个危险因素,应鼓励青少年永不开始吸烟,或如果已经吸烟则戒烟。虽然异位妊娠在成年人中更易发生,但青少年也有风险,早期诊断有助于进行保守治疗。
任何出现闭经、疼痛或阴道出血的青少年都应评估是否可能为异位妊娠。青少年比成年人更易出现疼痛症状。应进行经阴道超声检查,如果未清楚看到宫内妊娠或异位妊娠,则需将其与血清β-人绒毛膜促性腺激素水平进行关联分析。如果β-人绒毛膜促性腺激素水平高于1500 mIU的“鉴别阈”,且经阴道超声未显示宫内妊娠,则应怀疑为异位妊娠。
未破裂的异位妊娠可采用期待治疗、手术治疗或药物治疗(甲氨蝶呤)。健康的、未破裂异位妊娠且能够并愿意接受密切监测的青少年可用甲氨蝶呤治疗。有青少年异位妊娠用甲氨蝶呤成功治疗的病例报告。