双相情感障碍患者在恐惧感知过程中的皮质纹状体活动异常。
Abnormal corticostriatal activity during fear perception in bipolar disorder.
作者信息
Killgore William D S, Gruber Staci A, Yurgelun-Todd Deborah A
机构信息
Cognitive Neuroimaging Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA.
出版信息
Neuroreport. 2008 Oct 8;19(15):1523-7. doi: 10.1097/WNR.0b013e328310af58.
Abstract
The time course of responses to repeated presentations of affective stimuli is well characterized in healthy individuals but remains to be characterized in patients with bipolar disorder. Using functional magnetic resonance imaging, we compared early-stage and late-stage brain activation during a two-block fearful face perception task in 14 adult bipolar patients to that of 13 healthy controls. Whereas control participants showed increased orbitofrontal, anterior cingulate, and striatum activity during the late (vs. early) stage of the task, bipolar patients failed to show normal task-related activity in these regions. Results suggest that bipolar disorder may involve corticostriatal dysfunction.
摘要
在健康个体中，对情感刺激重复呈现的反应时间进程已得到充分描述，但在双相情感障碍患者中仍有待描述。我们使用功能磁共振成像，在一项两阶段恐惧面孔感知任务中，比较了14名成年双相情感障碍患者与13名健康对照者早期和晚期的大脑激活情况。在任务的晚期（相对于早期），对照参与者的眶额皮质、前扣带回和纹状体活动增强，而双相情感障碍患者在这些区域未表现出正常的任务相关活动。结果表明，双相情感障碍可能涉及皮质纹状体功能障碍。
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