Souraty Pierre, Nast Cynthia C, Mehrotra Rajnish, Barba Lilly, Martina John, Adler Sharon G
Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute, Torrance, CA, USA.
Nat Clin Pract Nephrol. 2008 Nov;4(11):639-42. doi: 10.1038/ncpneph0946. Epub 2008 Sep 16.
A 56-year-old man with previously treated hepatitis C presented to a nephrology clinic with hypertension, proteinuria and declining renal function. His medical history included previous smoking, prior hip replacements with prolonged osteomyelitis, and left renal artery stenosis. Diabetes mellitus was ruled out by a 2 h oral glucose tolerance test and two glycated hemoglobin (HbA 1c) measurements. A renal biopsy showed evidence of nodular glomerulosclerosis.
Physical examination, renal biopsy, and urine and blood analyses including an oral glucose tolerance test.
Nodular glomerulosclerosis and metabolic syndrome.
Patients with metabolic syndrome should be screened for evidence of renal injury since clinical and histological nodular glomerulosclerosis identical to diabetic nephropathy can occur in this setting. Early diagnosis and treatment of albuminuria could alter the course of disease progression.
一名56岁曾接受过丙型肝炎治疗的男性因高血压、蛋白尿和肾功能下降就诊于肾脏病诊所。他的病史包括既往吸烟、曾行髋关节置换术且伴有长期骨髓炎以及左肾动脉狭窄。通过2小时口服葡萄糖耐量试验和两次糖化血红蛋白（HbA 1c）测量排除了糖尿病。肾活检显示有结节性肾小球硬化的证据。
体格检查、肾活检以及尿液和血液分析，包括口服葡萄糖耐量试验。
结节性肾小球硬化和代谢综合征。
代谢综合征患者应筛查肾损伤证据，因为在此情况下可出现与糖尿病肾病相同的临床和组织学结节性肾小球硬化。早期诊断和治疗蛋白尿可能会改变疾病进展过程。
