Sharif Saima, O'Connell Michael J, Yothers Greg, Lopa Samia, Wolmark Norman
National Surgical Adjuvant Breast and Bowel Project Operations Office, Pittsburgh, Pennsylvania, USA.
Cancer Invest. 2008 Nov;26(9):956-63. doi: 10.1080/07357900802132550.
The MOSAIC trial showed that the use of adjuvant oxaliplatin and an infusional regimen of 5-FU/LV in the treatment of stage II/III colon cancer improved disease-free survival (DFS). The NSABP's C-07 trial evaluated the addition of oxaliplatin to a weekly Roswell Park regimen of bolus 5-FU/LV and found a similar improvement in DFS. The benefit of oxaliplatin appears to be independent of the 5-FU/LV regimen used. This paper reviews the efficacy and toxicities of these two regimens and is meant to serve as a guide for clinical practice.
MOSAIC试验表明，在II/III期结肠癌治疗中使用奥沙利铂辅助治疗以及5-氟尿嘧啶/亚叶酸钙的输注方案可改善无病生存期（DFS）。NSABP的C-07试验评估了在罗兹威尔帕克每周大剂量5-氟尿嘧啶/亚叶酸钙方案中添加奥沙利铂的效果，发现DFS也有类似改善。奥沙利铂的益处似乎与所用的5-氟尿嘧啶/亚叶酸钙方案无关。本文回顾了这两种方案的疗效和毒性，旨在作为临床实践的指南。
