Hsiao Sonny C, Crow Ailey K, Lam Wilbur A, Bertozzi Carolyn R, Fletcher Daniel A, Francis Matthew B
Department of Chemistry, University of California, Berkeley.
Angew Chem Int Ed Engl. 2008;47(44):8473-7. doi: 10.1002/anie.200802525.
Measurement of receptor adhesion strength requires the precise manipulation of single cells on a contact surface. To attach live cells to a moveable probe, DNA sequences complementary to strands displayed on the plasma membrane are introduced onto AFM cantilevers (see picture, bp=base pairs). The strength of the resulting linkages can be tuned by varying the length of DNA strands, allowing for controlled transport of the cells
测量受体黏附强度需要在接触表面精确操控单个细胞。为了将活细胞附着到可移动探针上，将与质膜上展示的链互补的DNA序列引入原子力显微镜（AFM）悬臂（见图，bp =碱基对）。通过改变DNA链的长度可以调节所得连接的强度，从而实现对细胞的可控运输。
