使用金纳米壳的光热疗法与传统光动力疗法联合治疗以提高治疗效果：一项体外研究。
Combinatorial treatment of photothermal therapy using gold nanoshells with conventional photodynamic therapy to improve treatment efficacy: an in vitro study.
作者信息
Kah James Chen Yong, Wan Rachel Cheng Yi, Wong Ker Yi, Mhaisalkar Subodh, Sheppard Colin James Richard, Olivo Malini
机构信息
Division of Bioengineering, National University of Singapore, 7 Engineering Drive 1, Singapore 117574, Singapore.
出版信息
Lasers Surg Med. 2008 Oct;40(8):584-9. doi: 10.1002/lsm.20674.
BACKGROUND AND OBJECTIVE
Both photodynamic (PDT) and photothermal (PTT) therapy have proven to be effective treatment strategies for cancer, but the approach of combining them into a single treatment modality may offer better treatment efficacy. We compare the treatment efficacy of such combined treatment with the individual treatment.
STUDY DESIGN/MATERIALS AND METHODS: We perform the individual PDT, PTT and combined treatment under selected in vitro condition with our low light dose of 1.44 J/cm(2) and compare their cell viability using crystal fast violet assay.
RESULTS
Compared to PDT and PTT alone which can reduce cell viability to 30.9% and 44.0% respectively, the combined treatment under a single irradiation can further reduce the cell viability to 17.5%.
CONCLUSION
A combined PDT and PTT treatment appears to be a more effective treatment strategy compared to conventional PDT or emerging PTT treatment.
背景与目的
光动力疗法（PDT）和光热疗法（PTT）均已被证明是治疗癌症的有效策略，但将它们结合成单一治疗方式可能会提供更好的治疗效果。我们比较了这种联合治疗与单独治疗的疗效。
研究设计/材料与方法：我们在选定的体外条件下，使用1.44 J/cm²的低光剂量进行单独的光动力疗法、光热疗法及联合治疗，并使用结晶紫测定法比较它们的细胞活力。
结果
与单独的光动力疗法和光热疗法相比，单独的光动力疗法可将细胞活力降低至30.9%，光热疗法可将细胞活力降低至44.0%，而单次照射下的联合治疗可进一步将细胞活力降低至17.5%。
结论
与传统的光动力疗法或新兴的光热疗法相比，光动力疗法与光热疗法联合治疗似乎是一种更有效的治疗策略。
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