Chadwick Samantha J, Salah Dina, Livesey Penelope M, Brust Mathias, Volk Martin
Department of Chemistry, University of Liverpool , Crown Street, Liverpool L69 7ZD, United Kingdom.
Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, United Kingdom; Biophysics Group, Physics Department, Ain Shams University, Cairo, Egypt.
J Phys Chem C Nanomater Interfaces. 2016 May 19;120(19):10647-10657. doi: 10.1021/acs.jpcc.6b02005. Epub 2016 May 5.
The formation of singlet oxygen by irradiation of gold nanoparticles in their plasmon resonance band with continuous or pulsed laser light has been investigated. Citrate-stabilized nanoparticles were found to facilitate the photogeneration of singlet oxygen, albeit with low quantum yield. The reaction caused by pulsed laser irradiation makes use of the equilibrated hot electrons that can reach temperatures of several thousand degrees during the laser pulse. Although less efficient, continuous irradiation, which acts via the short-lived directly excited primary "hot" electrons only, can produce enough singlet oxygen for photodynamic cancer therapy and has significant advantages for practical applications. However, careful design of the nanoparticles is needed, since even a moderately thick capping layer can completely inhibit singlet oxygen formation. Moreover, the efficiency of the process also depends on the nanoparticle size.
研究了用连续或脉冲激光照射处于等离子体共振带的金纳米颗粒形成单线态氧的情况。发现柠檬酸盐稳定的纳米颗粒有助于单线态氧的光生，尽管量子产率较低。脉冲激光照射引起的反应利用了在激光脉冲期间能达到数千度温度的平衡热电子。虽然效率较低，但仅通过短寿命的直接激发初级“热”电子起作用的连续照射可以产生足够用于光动力癌症治疗的单线态氧，并且在实际应用中有显著优势。然而，由于即使是适度厚的包覆层也能完全抑制单线态氧的形成，因此需要对纳米颗粒进行精心设计。此外，该过程的效率还取决于纳米颗粒的尺寸。
