Winchester David E, Ragosta Michael, Taylor Angela M
University of Virginia, Charlottesville, Virginia, USA.
Catheter Cardiovasc Interv. 2008 Nov 1;72(5):612-6. doi: 10.1002/ccd.21738.
To determine the coexistence of coronary artery disease (CAD) in an unselected cohort of patients with apical ballooning syndrome (ABS).
ABS is a clinical condition of unknown etiology with symptoms that mimic an acute coronary syndrome and is characterized by the presence of transient left ventricular dysfunction primarily affecting the apex of the heart.
We conducted a retrospective case series in a single tertiary care hospital. Patients were identified by searching for several inclusive discharge diagnoses in all hospitalized patients. Suspected cases were analyzed using prespecified diagnostic criteria. Demographic, clinical, and imaging data were collected. Coronary lesions were assessed by quantitative angiography.
Thirty-one cases of ABS were identified. The majority of the cases were female, and ischemia was documented in all patients by electrocardiographic or cardiac biomarker criteria. Nineteen patients (61.3%) had angiographic evidence of CAD, with multivessel involvement in seven (23%). Nine patients (29%) had luminal stenosis severity greater than 50% in at least one epicardial vessel.
In an unselected cohort of patients with ABS, coronary atherosclerosis is commonly present. Whether CAD simply coexists or is related to the pathophysiology of ABS is unclear.
确定在未经选择的一组心尖球囊综合征（ABS）患者中冠状动脉疾病（CAD）的共存情况。
ABS是一种病因不明的临床病症，其症状类似于急性冠状动脉综合征，其特征是存在主要影响心尖的短暂性左心室功能障碍。
我们在一家三级医疗中心进行了一项回顾性病例系列研究。通过在所有住院患者中搜索几种包容性出院诊断来识别患者。使用预先指定的诊断标准对疑似病例进行分析。收集人口统计学、临床和影像学数据。通过定量血管造影评估冠状动脉病变。
共识别出31例ABS患者。大多数病例为女性，所有患者均通过心电图或心脏生物标志物标准记录有心肌缺血。19例患者（61.3%）有CAD的血管造影证据，其中7例（23%）为多支血管受累。9例患者（29%）至少有一支心外膜血管的管腔狭窄严重程度大于50%。
在未经选择的一组ABS患者中，冠状动脉粥样硬化普遍存在。CAD是单纯共存还是与ABS的病理生理学有关尚不清楚。
