Huang Pu, Gou Wen-li, Jiang Ma-li, Zhang Rui, Sun Yun-ping
Department of Obstetrics and Gynecology, The First Affiliated Hospital, Medical School of Xi' an Jiaotong University, Xi' an 710061, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Jul;39(4):627-30.
To test the impact of fetal growth restriction (FGR) on the spatial learning and memory abilities of the offspring of rats.
FGR Model of Sprague-Dawley rats was constructed according to the method of passive smoking. The offspring of the rats were divided into male FGR group, male control group, female FGR group and female control group. Within each group, the rats were randomly divided into three subgroups to be tested at 1, 2, and 4 months of age, respectively (n =10 for each subgroup). Morris water maze task was performed to assess the spatial learning and memory abilities of the rats.
The escape latencies to find the platform were shortened with increased training times for all of the rats. At the age of 1 and 2 months, both male and female rats in the FGR group spent more time in finding the platform than their counterparts in the control group (P < 0.05). At the age of 4 months, significant prolonged latency was only found in the female rats. The rats in the FGR group, except the 4 months old male rats, were more likely to use non-effective strategies (random or marginal strategies) to find the platform than the efficient strategies (tendency or straight strategies). The rats in the FGR group stayed in the platform shorter than those in the control groups (P < 0.05).
FGR can cause gender- and age-specific impairment of spatial learning and memory abilities to the offspring.
检测胎儿生长受限（FGR）对大鼠后代空间学习和记忆能力的影响。
按照被动吸烟法构建Sprague-Dawley大鼠FGR模型。将大鼠后代分为雄性FGR组、雄性对照组、雌性FGR组和雌性对照组。每组内大鼠随机分为三个亚组，分别在1、2和4月龄时进行测试（每个亚组n = 10）。采用Morris水迷宫任务评估大鼠的空间学习和记忆能力。
所有大鼠找到平台的逃避潜伏期均随训练次数增加而缩短。在1和2月龄时，FGR组的雄性和雌性大鼠找到平台的时间均比对照组的对应大鼠长（P < 0.05）。在4月龄时，仅在雌性大鼠中发现潜伏期显著延长。FGR组的大鼠，除4月龄雄性大鼠外，与采用有效策略（趋向或直线策略）相比，更倾向于使用无效策略（随机或边缘策略）来寻找平台。FGR组的大鼠在平台上停留的时间比对照组短（P < 0.05）。
FGR可导致后代出现性别和年龄特异性的空间学习和记忆能力损害。
