Xie Ping, Xie Yong-mei, Song Hang, Song Xin, Zuo Yuan-jie, Qiu Yu, Tang Xiao-hai
Institute of Chemical Engineering, Sichuan University, Chengdu 610065, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Jul;39(4):648-50.
To prepare esomeprazole zinc solid dispersion (EZSD) to improve its dissolution in vitro.
EZ solid dispersions were prepared by solvent method using PVP K30 and PEG 6000 as carriers. The in vitro dissolution of the EZ solid dispersions enteric capsules was analyzed. The existence status of EZ in the carrier was determined by differential scanning calorimeter (DSC).
The dissolution of EZ increased first and then decreased with the increase of the ratio of carries. The dissolution of the solid dispersions with PEG 6000 as carrier was faster than that with PVP K30 as carrier. The EZ was amorphously dispersed in the solid dispersion.
The in vitro dissolution rate of EZ is significantly improved by the solid dispersion.
制备埃索美拉唑锌固体分散体（EZSD）以提高其体外溶出度。
采用溶剂法，以聚乙烯吡咯烷酮K30（PVP K30）和聚乙二醇6000（PEG 6000）为载体制备EZ固体分散体。分析EZ固体分散体肠溶胶囊的体外溶出情况。通过差示扫描量热法（DSC）确定EZ在载体中的存在状态。
随着载体比例的增加，EZ的溶出度先升高后降低。以PEG 6000为载体的固体分散体的溶出速度比以PVP K30为载体的固体分散体快。EZ以无定形形式分散在固体分散体中。
固体分散体显著提高了EZ的体外溶出速率。
