Pantić Milica, Kravanja Katja Andrina, Knez Željko, Novak Zoran
Faculty of Chemistry and Chemical Engineering, Laboratory of Separation Processes and Product Design, University of Maribor, Smetanova 17, 2000 Maribor, Slovenia.
Faculty of Medicine, University of Maribor, Taborska Ulica 8, 2000 Maribor, Slovenia.
Polymers (Basel). 2021 Jun 6;13(11):1882. doi: 10.3390/polym13111882.
The presented study shows the possibility of using bioaerogels, namely neat alginate, pectin, chitosan aerogels, and alginate and pectin aerogels coated with chitosan, as drug delivery systems for esomeprazole. Two different techniques were used for the impregnation of esomeprazole: Supercritical impregnation, and diffusion via ethanol during the sol-gel synthesis. The prepared samples were characterized by employing N adsorption-desorption analysis, TGA/DSC, and FTIR. The achieved loadings were satisfactory for all the tested samples and showed to be dependent on the technique used for impregnation. In all cases, higher loadings were achieved when impregnation via diffusion from ethanol was used. Extensive release studies were performed for all impregnated samples. The in vitro dissolution profiles were found to be dependent on the carrier and impregnation method used. Most importantly, in all cases more controlled and delayed release was achieved with the bioaerogels compared to using pure esomeprazole.
本研究表明，使用生物气凝胶，即纯藻酸盐、果胶、壳聚糖气凝胶以及壳聚糖包覆的藻酸盐和果胶气凝胶作为埃索美拉唑的药物递送系统是可行的。采用了两种不同的技术来负载埃索美拉唑：超临界浸渍法，以及在溶胶-凝胶合成过程中通过乙醇扩散负载法。通过N吸附-脱附分析、热重/差示扫描量热法（TGA/DSC）和傅里叶变换红外光谱（FTIR）对制备的样品进行了表征。所有测试样品的载药量均令人满意，且表明其取决于负载技术。在所有情况下，当采用通过乙醇扩散负载法时，载药量更高。对所有负载样品进行了广泛的释放研究。发现体外溶出曲线取决于所用的载体和负载方法。最重要的是，在所有情况下，与使用纯埃索美拉唑相比，生物气凝胶实现了更可控和延迟的释放。
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